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Effect of Propofol on Cardioprotective Role of Remote Ischemic Preconditioning (RIPC)

Myocardial Infarction Clinical Trial

Official title:
Effect of Propofol on Cardioprotective Role of Remote Ischemic Preconditioning (RIPC)

Clinical Trial Summary

This study involves research using human subjects (cardiac surgical patients) to evaluate the effect of remote ischemic preconditioning (RIPC) on cardioprotective outcomes. RIPC applied to upper or lower extremities has been shown cardioprotective role by lowering release of cardiac troponin in patients with cardiac diseases. However, it is not clear whether anesthetics, such as propofol or sevoflurane, may impair the cardioprotective effect of RIPC in cardiac surgical patients. Therefore, the purpose of the study is to compare the effects of anesthetics on cardioprotection of RIPC in patients undergoing cardiac surgery.

Clinical Trial Description

Patients undergoing cardiac surgery using cardiopulmonary bypass will be randomized to control, propofol, or sevoflurane group. Patients in the control group will receive remote ischemic preconditioning (RIPC) on their upper arms before anesthetic induction. Patients in the propofol or sevoflurane groups will receive RIPC after anesthetic induction using propofol or sevoflurane, respectively. In all patients, arterial blood samples will be obtained before and after each RIPC. From the samples, human dialysate will be obtained and perfused to rat heart through Langendorff apparatus before ischemia-reperfusion injury to the rat heart. Infarct size of the sectioned rat heart will be compared among the three - control, propofol, and sevoflurane - groups. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02932722
Study type Interventional
Source Seoul National University Hospital
Contact
Status Completed
Phase N/A
Start date February 22, 2017
Completion date February 7, 2018
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