Myocardial Infarction Clinical Trial
Official title:
Inflammatory Response in Myocardial Infarction Evaluated by MRI and Biomarkers of Inflammation
An intense inflammatory reaction is triggered by the ischemic injury during myocardial
infarction. The inflammatory processes involved are complex and haven't been explored in
detail in human patients. This inflammatory response can increase myocardial damage following
reperfusion, leading to adverse remodeling and adverse events (heart failure, sudden cardiac
death).
Cardiac MRI can assess the size of myocardial infarction and many other parameters associated
with myocardial injury: edema, hemorrhage, micro-vascular obstruction.
(However the association between biomarkers of inflammation and these imaging parameters is
not known).
There is very little data correlating imaging markers of myocardial injury to the biokinetics
of inflammation biomarkers.
In this study, the aim is to assess the relationship between the kinetics of specific
inflammatory biomarkers (interleukin-1beta, interleukin 6, interleukin 17, Tumor Necrosis
Factor (TNF)-alpha, C reactive protein (CRP), soluble toll-like receptor-2 (ST2),
neutrophils) and imaging markers of injury measured by cardiac MRI at the acute phase in 20
acute mycardial infarction (AMI) patients.
n/a
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