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NCT02364687 Clinical Trial

Optimisation and Quantification of Contrast Enhanced Computed Tomography Myocardial Fibrosis Imaging

Myocardial Infarction Clinical Trial

Official title:
Optimisation and Quantification of Contrast Enhanced Computed Tomography

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02364687
Other study ID # 13/SS/0152
Secondary ID
Status Completed
Phase
First received
Last updated
Start date October 2013
Est. completion date May 2023

Study information
Verified date June 2022
Source University of Edinburgh
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Detecting scarred heart muscle is important to diagnose and treat of a wide variety of heart conditions. Magnetic resonance imaging (MRI) can assess scarred heart muscle but it is time consuming, contraindicated for some patients and not tolerated by others. Computed tomography (CT) imaging has the potential to provide a rapid comprehensive assessment of the heart. This study will assess CT imaging of the heart muscle of patients who have previously undergone MRI of their heart. Using a state of the art CT scanner the investigators will develop a low radiation dose protocol to identify scarred heart muscle. The investigators will use and develop software techniques to analyse these images. This will enable us to develop a new way to identify and measure scarred heart muscle that will benefit patients with heart disease.

Recruitment information / eligibility
Status Completed
Enrollment 40
Est. completion date May 2023
Est. primary completion date December 2015
Accepts healthy volunteers No
Gender All
Age group 40 Years and older
Eligibility Inclusion Criteria: - Presence of late enhancement on magnetic resonance imaging Exclusion Criteria: - age less than 40 - inability or unwillingness to undergo CT - renal failure (serum creatinine >200 umol/l or estimated glomerular filtration rate <30 ml/min) - hepatic failure - allergy to iodinated contrast - pregnancy - breast feeding - inability to undergo informed consent - fast atrial fibrillation

Study Design

Related Conditions & MeSH terms

Intervention

Radiation:
• Computed tomography late enhancement imaging

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
University of Edinburgh

Outcome
Type Measure Description Time frame Safety issue
Primary Myocardial late enhancement The amount of myocardial late enhancement measured on computed tomography as compared to magnetic resonance imaging. Immediate
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