Myocardial Infarction Clinical Trial
Official title:
Effects of Recombinant Human Erythropoietin on Platelet Function in Patients With Acute Myocardial Infarction
The purpose of this study is to see if a naturally-occurring hormone called erythropoietin changes the action of platelets in the blood. Patients with heart attacks are treated with medicines to reduce the clotting action of platelets. This study is trying to determine whether erythropoietin alters the clotting action of platelets in patients receiving anti-platelet medicines. It is important to understand the effects of erythropoietin on platelets since preliminary studies in animals suggest that erythropoietin may protect the heart from damage during a heart attack.
Anti-apoptotic effects of erythropoietin in experimental myocardial infarction (MI) and
ischemia-reperfusion injury suggest potential for therapeutic benefit in patients with acute
MI. Before the therapeutic potential of recombinant human erythropoietin (rHuEpo) in acute MI
can be tested in large clinical trials, more information on the effects of short-term rHuEpo
on platelet function are needed. Accordingly, the current proposal aims to determine the
effects of rHuEpo (at a dose previously shown not to inhibit the anti-platelet effects of
aspirin and clopidogrel in healthy subjects) on platelet function and other safety measures
and measure of infarct size in patients with acute coronary syndromes receiving
clinically-indicated standard anti-platelet therapy with aspirin, clopidogrel and
glycoprotein Iib-IIIa inhibitors.
Specific Aim 1: To determine the effects of intravenous rHuEpo 400 U/kg daily for 3 days vs.
placebo on in vivo and in vitro platelet function in patients with acute MI undergoing
percutaneous revascularization.
Specific Aim 2: To obtain pilot data to estimate the effects of administration of rHuEpo 400
U/kg daily for 3 days vs. placebo on biochemical markers of myocardial infarction size and
left ventricular ejection fraction in patients with acute MI undergoing percutaneous
revascularization
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