Myocardial Infarction Clinical Trial
Official title:
Prevention of Reperfusion Damage and Late Left Ventricular Remodelling With Atorvastatin Administered Before Reperfusion Therapy. The REPERATOR Study
The purpose of this study is to determine if oral atorvastatin administered just before percutaneous coronary angioplasty for acute myocardial infarction improves early and late heart function as compared to placebo.
Left ventricular remodelling after a myocardial infarction refers to changes in shape and
function of the infarcted and uninfarcted myocardium. Remodelling begins minutes after acute
myocardial infarction and may continue for months or years, leading to dilation of the left
ventricle (LV) and an increased LV volume. As studies show, LV volume strongly correlates
with long-term mortality. Reperfusion after a period of ischaemia (through medication or
PTCA) leads to so-called 'reperfusion injury'. This results in myocardial dysfunction and
damage, which can lead to LV remodelling.
In a study where atorvastatin was administered at the onset of reperfusion infarct size was
reduced. Atorvastatin led to protection of the reperfused myocardium, independently of its
effects on cholesterol.
The objective is to measure the effect of atorvastatin, administered orally before
reperfusion therapy by PTCA, on infarct size and microvascular reperfusion.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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