Myelodysplastic Syndromes Clinical Trial
Official title:
Multicenter Prospective Observational Study of the Outcome of Patients With Acute Myeloblastic Leukemia (AML) and Myelodysplastic Syndrome (MDS) Receiving Iron Chelation Therapy (Exjade) After Allogeneic Hematopoietic Stem Cell Transplantation (Allo-HSCT)
Iron chelation, mostly associated with multiple red blood cell transfusion, is relatively
common in patients with hematological malignancies receiving allo-HSCT.
This multicenter prospective observational study is designed to establish the impact of iron
chelation on relapse after allo-HSCT in patients with acute myeloid leukemia and
myelodysplastic syndrome. The investigators will compare the results obtained in the
prospective study to those observed in a historical retrospective cohort of paired patients
who did not receive chelation. Given our clinical experience and literature results, the
investigators will evaluate the Exjade chelator. Although not demonstrated, the presence of
mutations of the HFE gene could play an indirect role on leukemogenesis by promoting
overload. It is therefore important to evaluate the status in this patient population.
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