Clinical Trials Logo

Clinical Trial Summary

The risk of muscle wasting, and sarcopenia is high in the intensive care unit patients and associated with adverse clinical outcomes. The etiology of muscle wasting is multifactorial and medical nutrition therapy plays a key role in treatment and prevention. The purpose of this study is to evaluate the effect of omega-3 fatty acids in the treatment and/or prevention of muscle wasting in critically ill trauma patients.


Clinical Trial Description

Low skeletal muscle mass and loss of lean tissue in critically illness have been associated with negative clinical outcomes. Critically ill patients may lose about 25% of their skeletal muscle mass within 7 days of admission to the intensive care unit. Besides increased protein catabolism, other factors inherent to the ICU environment contribute to muscle loss, including patient immobility and interruptions in nutrient delivery. This combination of factors is especially debilitating in patients with preexisting low muscle stores due to sarcopenia, chronic illness, or malnutrition. Although preservation of skeletal muscle mass is important for recovery in critically ill patients, the mechanism of muscle wasting is not unknown. Muscle wasting is a multifactorial process and it may be the consequence of several events, including oxidative stress, inflammatory conditions and muscle remodeling. Omega-3 fatty acids with their anti-inflammatory, antioxidant and anabolic effects can be a key factor for an effective treatment. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04582630
Study type Observational
Source Karadeniz Technical University
Contact
Status Enrolling by invitation
Phase
Start date July 20, 2020
Completion date December 20, 2021

See also
  Status Clinical Trial Phase
Recruiting NCT06104527 - Indicator Amino Acid Oxidation in ICU Patients N/A
Active, not recruiting NCT01624792 - Eicosapentaenoic Acid and Protein Modulation to Induce Anabolism in Chronic Obstructive Pulmonary Disease (COPD): Aim 2 N/A
Completed NCT02270502 - Effects of Frailty, Sarcopenia and Muscle Wasting on Outcomes of Patients in the Surgical Intensive Care Unit N/A
Completed NCT02391103 - Effects of Neuromuscular Electrical Stimulation on Muscle Mass and Strength in Critically Ill Patients After Cardiothoracic Surgery N/A
Completed NCT05210205 - Physiological Response to Protein and Energy-enhanced Food Products During Winter Military Training N/A
Completed NCT01372176 - Early Goal-Directed Nutrition in ICU Patients - EAT-ICU Trial Phase 4
Completed NCT04789031 - Muscle Status to Oral Nutritional Supplementation in Hemodialysis Patients With Protein Energy Wasting N/A
Completed NCT01355497 - Effect of GTx-024 on Muscle Wasting in Patients With Non-Small Cell Lung Cancer (NSCLC) on First Line Platinum Phase 3
Completed NCT01355484 - Phase III Study of the Effect of GTx-024 on Muscle Wasting in Patients With Non-Small Cell Lung Cancer (NSCLC) Phase 3
Completed NCT03560713 - Effects of Functional Electrical Stimulation in Patients Undergoing Coronary Artery Bypass Grafting Surgery N/A
Completed NCT03026985 - Acute Skeletal Muscle Wasting and Relation to Physical Function in Patients Requiring ECMO N/A
Completed NCT02057094 - Effects of Protein Supplementation on Lean Body Mass Recovery From Extreme Military Training N/A
Completed NCT04698798 - Skeletal Muscle Wasting in SARS-CoV-2 N/A
Recruiting NCT06250686 - Exercise and Nutrition Intervention in Ovarian Cancer N/A
Completed NCT04744142 - Effects of Ketones on Muscle Wasting During Caloric Restriction in Lean Females N/A
Completed NCT06167772 - Leucine-enriched Branched-chain Amino Acid on Muscle Thickness, Interleukin-6, SOFA Score in Critical Illness N/A
Recruiting NCT04353063 - Muscle Wasting in Children and Adolescents With Cancer N/A
Completed NCT01321320 - Investigation of the Role of FHL-1 and Myostatin in Intensive Care Unit Acquired Paresis (ICUAP) N/A
Completed NCT04266015 - Anabolic Effects of Intraoperative Feeding in Reconstruction Surgery N/A
Recruiting NCT04889235 - Diaphragm Kinetics Following Hepatic Resection