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Clinical Trial Summary

Primary Objectives:

To evaluate response rates of acute or chronic Graft-versus-host disease (GVHD) following CD8 depleted DLI (Depleted Donor Lymphocyte Infusions) in patients with Chronic myelomonocytic leukemia (CMML), chronic lymphoid leukemia (CLL), Non-Hodgkin's lymphoma (NLM), Multiple Myeloma (MM) and Hodgkin's Lymphoma (HD).

Secondary Objectives:

- To evaluate safety and treatment related mortality after CD8 depleted DLI.

- To evaluate the time to onset of GVHD following DLI and response to GVHD treatment.

- To evaluate the incidence and timing of pancytopenia following DLI.

- To evaluate disease-free survival, overall survival and relapse rates in three cohorts of patients; early relapse CML, late relapse CML and lymphoproliferative disorders (HD, CLL, NHL and MM).

- To evaluate the need and efficacy of second or subsequent CD8 depleted donor lymphocyte infusions.

- To evaluate the number of apheresis procedures needed to collect appropriate doses of CD4+ cells.


Clinical Trial Description

n/a


Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms


NCT number NCT00038818
Study type Interventional
Source M.D. Anderson Cancer Center
Contact
Status Terminated
Phase N/A
Start date May 2001
Completion date December 2002

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