Moyamoya Disease Clinical Trial
Official title:
Moyamoya Disease Biomarkers in Patients With Intracranial Atherosclerotic Stroke
The aim of this study is to investigate the proportion of patients with moyamoya disease among the patients who were diagnosed as having intracranial atherosclerotic stroke. To do this, biomarkers (gene and imaging) for moyamoya disease are tested and follow up angiography are performed during follow up (in selected patients).
Status | Recruiting |
Enrollment | 400 |
Est. completion date | December 2019 |
Est. primary completion date | December 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 20 Years and older |
Eligibility |
Inclusion Criteria: 1. Intracranial atherosclerotic stroke - Patients with age over 20 years - Patients with focal neurological deficits presented within 7 days of symptom onset - Patients with acute ischemic lesions on diffusion-weighted image (DWI) - Patients with stenosis on the relevant intracranial vessels (distal ICA and/ or M1) 2. Moyamoya disease - Patients with age over 20 years - Patients who performed conventional angiography - Patients who are diagnosed as having either definite or probable Moyamoya disease 3. Healthy subjects - Subjects with age over 20 years - Subjects with no history of cerebrovascular disease Exclusion Criteria: - Patients with extracranial stenosis more than 50% - Patients with potential sources of cardio-aortic embolism - Patients with moderate to severe renal disease - Pregnancy or lactation - Patients with short life expectancy |
Country | Name | City | State |
---|---|---|---|
Korea, Republic of | Department of Neurology, Samsung Medical Center | Seoul |
Lead Sponsor | Collaborator |
---|---|
Samsung Medical Center |
Korea, Republic of,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Frequency of RNF213 gene variants and HR-MRI findings in patients with intracranial atherosclerosis | Anytime during study period (in intracranial atherosclerosis, HR-MRI findings within 2 weeks) | ||
Secondary | Frequency of typical angiographic findings of moyamoya disease at follow up conventional angiography in patients with intracranial atherosclerosis who showed typical gene and imaging biomarkers of moyamoya disease | Within 2 years |
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