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Mitral Valve Insufficiency clinical trials

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NCT ID: NCT04666480 Terminated - Clinical trials for Degenerative Mitral Valve Disease

Early Feasibility Study of the PLAR Implant and Delivery System to Treat Degenerative Mitral Regurgitation

EXPLORE DMR
Start date: April 30, 2021
Phase: N/A
Study type: Interventional

An early feasibility study to evaluate the safety and feasibility of the PLAR Implant and Delivery System to treat severe degenerative mitral regurgitation and to gather preliminary data on its performance thereby providing guidance for future clinical development. The study is a single-arm registry with the last follow-up visit at 5 years post-intervention. The study will enroll up to 10 patients at up to 4 centers in North America.

NCT ID: NCT04529928 Terminated - Atrial Fibrillation Clinical Trials

An Initial Evaluation of the Carillon Mitral Contour System for Treatment of Atrial Function Mitral Regurgitation

AFIRE
Start date: October 19, 2020
Phase: N/A
Study type: Interventional

The objective of this prospective, multi-center trial is to assess the effectiveness of the CARILLON Mitral Contour System in treating patients with moderate-to-severe atrial functional mitral regurgitation (aFMR)

NCT ID: NCT04393779 Terminated - Clinical trials for Severe Degenerative Mitral Regurgitation Due to Mid-segment Posterior Leaflet Prolapse

Observational Registry on the HARPOON Device

REPLICATE
Start date: October 2, 2020
Phase: N/A
Study type: Interventional

To collect data on the HARPOON™ Mitral Valve Repair System for use in patients with severe degenerative mitral regurgitation due to posterior leaflet prolapse.

NCT ID: NCT04382612 Terminated - Clinical trials for Mitral Regurgitation

Treatment of Mitral Regurgitation Using a Minimally Invasive Approach With the HARPOON Device.

ASCEND
Start date: October 2, 2020
Phase: N/A
Study type: Interventional

To evaluate the long-term safety and performance of the HARPOON™ MVRS for use in patients presenting with severe degenerative mitral regurgitation due to posterior leaflet prolapse in the post-market phase.

NCT ID: NCT04098328 Terminated - Clinical trials for Mitral Regurgitation

Early Feasibility EXperience of Posterior Leaflet RestOration to REduce Mitral Regurgitation

EXPLORE MR
Start date: January 1, 2020
Phase:
Study type: Observational [Patient Registry]

Early feasibility study, single-arm registry design

NCT ID: NCT03891823 Terminated - Clinical trials for Ventricular Remodeling, Left

Transcatheter Mitral Valve Repair for the Treatment of Mitral Valve Regurgitation In Heart Failure (The EVOLVE-MR Trial)

EVOLVE-MR
Start date: March 8, 2019
Phase: N/A
Study type: Interventional

The study compares the effectiveness of treatment with MitraClip to medical therapy in improving the reduction of cardiovascular morbidity and functional capacity at 24 months, in patients with moderate functional mitral regurgitation.

NCT ID: NCT03511716 Terminated - Clinical trials for Mitral Regurgitation

Observational Study of the Heart Repair Technologies Mitral Bridge in Treating Mitral Valve Regurgitation

HRT
Start date: February 6, 2014
Phase:
Study type: Observational

Prospective, observational, multi-center trial in which patients with mitral regurgitation sufficient to merit mitral valve repair will receive a surgical transvalvular, intra-annular Mitral Bridge™ to reduce or eliminate mitral regurgitation.

NCT ID: NCT03311295 Terminated - Clinical trials for Mitral Valve Insufficiency

MitrAl ValvE RepaIr Clinical Trial (MAVERIC Trial) - United States

MAVERIC US
Start date: April 3, 2018
Phase: N/A
Study type: Interventional

The objective of the study is to evaluate the safety and feasibility of the ARTO System in patients with mitral valve regurgitation (MR) associated with congestive heart failure (CHF).

NCT ID: NCT03285724 Terminated - Clinical trials for Mitral Valve Insufficiency

Safety and Performance Study of the Harpoon Mitral Valve Repair System

Start date: May 16, 2017
Phase: N/A
Study type: Interventional

The primary objective of this study is to evaluate the safety and performance of the Harpoon Medical Device. It is anticipated, that the Harpoon Medical Device will provide advantages over current surgical interventions including: 1) a small minimally invasive incision, 2) no sternotomy, 3) no cardiopulmonary bypass, 4) no aortic manipulation, 5) a direct path to the valve plane, 6) performed on a beating heart, 7) real-time TEE-guided ePTFE cordal length adjustment and 8) less complicated procedure that is teachable and adoptable.

NCT ID: NCT03016975 Terminated - Clinical trials for Mitral Regurgitation

Edwards Cardioband System ACTIVE Pivotal Clinical Trial (ACTIVE)

ACTIVE
Start date: June 1, 2017
Phase: N/A
Study type: Interventional

To establish the safety and effectiveness of the Edwards Cardioband System in patients with functional mitral regurgitation (FMR).