Miscarriage Clinical Trial
Official title:
Exploration of Allograft Humoral Rejection in Chronic Histiocytic Intervillositis
Chronic histiocytic intervillositis (CHI) is a rare condition with an incidence of 5 in 10,000 pregnancies. This rare condition is associated with placental inflammatory lesions leading to severe and recurrent obstetrical complications: intrauterine growth retardation (IUGR), fetal death in utero and miscarriage. The pathophysiological mechanisms of CHI are poorly understood, while the empirical treatments prescribed to prevent recurrence are cumbersome and of poor efficacy. Recent findings suggest that an alloimmune response may play a role. In a recent work, the investigators have demonstrated the role of maternal alloantibodies directed against fetal HLA antigens in two patients followed for recurrent IUGR associated with CHI. Their work suggests that a humoral alloimmune response directed against fetal HLA antigens mimics an allograft rejection process. The investigators propose to extend the preliminary results obtained in these patients to provide new insights into the pathophysiological mechanisms of CHI, and eventually to predict the risks of fetal loss.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05969574 -
Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages?
|
||
| Enrolling by invitation |
NCT01689428 -
Ism1 Versus EmbryoGen Media for Embryo Culture in Previous Pregnancy Loss Cases
|
Phase 3 | |
| Completed |
NCT00194844 -
Couples Miscarriage Healing Project:Randomized Trial
|
Phase 1/Phase 2 | |
| Recruiting |
NCT05789940 -
Hysteroscopy vs. Endouterine Aspiration in the Management of Trophoblastic Retention
|
N/A | |
| Recruiting |
NCT03628625 -
Letrozole Pretreatment With Misoprostol fInduction of Abortion In First-Trimester Missed Miscarriage
|
Phase 2 | |
| Not yet recruiting |
NCT05579756 -
Psychatric Impact of Miscarriage in Assiut University Hospital
|
||
| Not yet recruiting |
NCT05557201 -
Cohort of Patients Presenting Unexplained Recurrent Miscarriages and Identification of Early Miscarriage Recidivism Factors
|
||
| Not yet recruiting |
NCT05039853 -
Improving Mental Health Following Early PREgnancy Loss Using a Brief Cognitive Task
|
N/A | |
| Recruiting |
NCT01223482 -
A Study Looking at Women's Experiences After a Miscarriage
|
N/A | |
| Completed |
NCT04604366 -
Comparison of Vaginal Versus Sublingual Misoprostol in the Treatment of First Trimester Missed Miscarriage
|
Phase 2 | |
| Not yet recruiting |
NCT05103098 -
Sublingual Misoprostol In Medical Treatment of First Trimester Missed Miscarriage
|
N/A | |
| Not yet recruiting |
NCT05088720 -
Misoprostol for Management of Women With an Incomplete Miscarriage
|
N/A | |
| Not yet recruiting |
NCT05094375 -
Vaginal Misoprostol In Medical Treatment of First Trimester Missed Miscarriage
|
N/A | |
| Not yet recruiting |
NCT05088707 -
Sublingual Versus Vaginal Misoprostol In Medical Treatment of Second Trimestric Missed Miscarriage
|
N/A | |
| Recruiting |
NCT05304273 -
Comparison Between Letrozole and Mifepristone in Medical Termination of First Trimester Miscarriages
|
Phase 3 | |
| Not yet recruiting |
NCT05653414 -
Interest of a Short Early Psychological Care in Women With Miscarriage
|
N/A | |
| Recruiting |
NCT03976544 -
Natural Cycle Versus Hormone Replacement Therapy Cycle for a Frozen-thawed Embryo Transfer in PGT Patients
|
Phase 4 | |
| Completed |
NCT01916928 -
The Use of Cell Free Fetal DNA in the Maternal Blood in the Evaluation of Intrauterine Fetal Demise and Miscarriage
|
N/A | |
| Completed |
NCT03940495 -
Serum Kisspeptin: a Predictive Marker of Miscarriage or Not?
|
||
| Completed |
NCT04512820 -
Treatment of Missed Miscarriage With TRUCLEAR Tissue Removal System, a Feasiblity Study
|
N/A |