Efficacy & Safety of Thoracoscopic Morrow Surgery in the Treatment of

Status Recruiting

Clinical Trial Summary

This single-center, prospective, open-label, randomized, controlled clinical trial is designed to assess the efficacy and safety of the Thoracoscopic Morrow procedure in the treatment of hypertrophic obstructive cardiomyopathy. The primary objectives include investigating: Question 1: The efficacy and safety of two surgical modalities in patients presenting with left ventricular outflow tract obstruction and mid-left ventricular hypertrophy. Question 2: The impact of the two surgical procedures on hemodynamics in patients with left ventricular outflow tract obstruction, mid-left ventricular obstruction, and in individuals with or without organic valvular lesions. Question 3: The effects of the two surgical procedures on exercise capacity, quality of life, and long-term prognosis among patients with left ventricular outflow tract obstruction and central left ventricular obstruction, both with and without valvular lesions. Participants will be stratified into two groups. The experimental group will undergo thoracoscopic Morrow surgery, while the control group will undergo median open modified enlarged Morrow surgery.

Clinical Trial Description

This study is a single-center, prospective, open-label, randomized, controlled trial designed to investigate the therapeutic value of thoracoscopic Morrow procedure in patients with hypertrophic obstructive cardiomyopathy (HOCM). The study focuses on HOCM patients, with the modified extended Morrow procedure via median sternotomy considered as the 'gold standard treatment' in the control group. The objective is to explore the efficacy of the thoracoscopic Morrow procedure in improving exercise tolerance in HOCM patients, assess the short-term and long-term effectiveness, safety, as well as changes in cardiac function, cardiac structure, and myocardial fibrosis levels associated with thoracoscopic Morrow procedure in treating obstructive HOCM. ;

Study Design

Related Conditions & MeSH terms

Cardiomyopathies
Cardiomyopathy, Hypertrophic
Cardiomyopathy, Hypertrophic Obstructive
Hypertrophy
Minimally Invasive Surgery

Clinical Trial Details

NCT number	NCT06391788
Study type	Interventional
Source	China National Center for Cardiovascular Diseases
Contact	Xin Wang
Phone	13901036490
Email	fuwaiwangxin@188.com
Status	Recruiting
Phase	N/A
Start date	March 31, 2023
Completion date	March 31, 2025

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT06202053` - An Observational Study on the Quality of Life After Precise Lung Resection Through the Periareolar Incision
Not yet recruiting	`NCT06050161` - Evaluating Artisential Laparoscopic Instruments in Gynecologic Surgery	N/A
Active, not recruiting	`NCT04568993` - The TriggerHappy Trial	N/A
Recruiting	`NCT03427840` - Superior Hypogastric Plexus Blockade in Laparoscopic Hysterectomy
Recruiting	`NCT04211948` - Clinical Study Between Robotic and Open Surgery in Patients With Pancreatic Cancer	N/A
Completed	`NCT02505880` - Hypnosis Versus General Anesthesia in Pediatric Surgery: Clinical and Medico-economic Interests	N/A
Completed	`NCT04231903` - Myocardial Protection in Minimally Invasive Mitral Valve Surgery
Recruiting	`NCT04370496` - Safety of Minimally Invasive Surgery Using Endoscopic Stapler in Early Stage Cervical Cancer Patients (SOLUTION)	N/A
Completed	`NCT04206696` - Learning Curve for Minimally Invasive Oesophagectomy and Contrast With Open Procedure
Recruiting	`NCT04718272` - Safety and Feasibility of the Application of Thoracic Puncture Tube After Pulmonary Lobectomy	N/A
Recruiting	`NCT05971875` - RCT on 3 Types of Hysterectomy	N/A
Completed	`NCT06289816` - Spleen Preserving Surgery for Splenic Hydatidosis: A Cohort Study on Short and Long-Term Outcomes
Not yet recruiting	`NCT05173467` - Robot-assisted Invasion-controlled Surgery Versus Traditional-open Surgery Against Metastatic Spinal Tumor	N/A
Completed	`NCT02621710` - Goal Achievement and Patient Satisfaction in Benign Hysterectomy	N/A
Completed	`NCT03642743` - Patient Satisfaction With Postoperative Follow up After Minimally Invasive Hysterectomy	N/A
Recruiting	`NCT05019404` - Minimally Invasive Surgical Epilepsy Trial for Temporal Lobe Epilepsy	N/A
Recruiting	`NCT02085031` - Intracorporeal Versus Extracorporeal Roux-en-Y Esophagojejunostomy During Laparoscopic Total Gastrectomy for Gastric Cancer	Phase 2
Completed	`NCT06385210` - Barriers to Routine Surgical Video Recording	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Efficacy and Safety of Thoracoscopic Morrow Surgery in the Treatment of Hypertrophic Obstructive Cardiomyopathy

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms