Microcirculation Clinical Trial
Official title:
The Impact of Intra-operative Fluid Infusion Rate on Hemodilution and Microcirculation Prospective Observational Pilot Study
Intraoperative fluid therapy (IFT) is an integral part of anesthesia care during surgery. Its main indication is the optimization of oxygen supply to the tissues. For elective surgery that is not associated with higher blood loss and a long period of preoperative fasting, including fluids IFT is dosed to cover the basal daily need for fluids. However, it is not clear whether this fluid dose is optimal. Surgery is a stress factor that leads, among other things, to damage of the endothelial glycocalyx (EG). EG binds a significant amount of plasma, which is released during EG destruction and causes relative hemodilution. Isovolumic hemodilution is an established intraoperative procedure that serves to better control bleeding in procedures where bleeding is expected. However, partial hemodilution occurs even with standard IFT, and even when fluids are hardly given at all. Flow parameters in microcirculation have not yet been described depending on IFT conduction. The parameters of the microcirculation reflect its functioning, which will consequently affect the postoperative phase of the patient's moaning and clinical outcome.
Intraoperative fluid therapy (IFT) is an integral part of anesthesia care during surgery. Its main indication is the optimization of oxygen supply to the tissues. IFT is tailored to the surgical performance, blood loss, and patient (comorbidities, length of preoperative fasting, hydration level, volemia status). For elective surgery that is not associated with higher blood loss (< 200 ml) and a long period of preoperative fasting, including fluids (fluids per os < 2 hours before the procedure), IFT is dosed to cover the basal daily need for fluids (approx. 1-2 ml) /kg.hour-1). However, it is not clear whether this fluid intake is optimal. Surgery is a stress factor that leads, among other things, to damage of the endothelial glycocalyx (EG), which is a thin carbohydrate layer on the endoluminal side of endothelial cells, which is of fundamental importance for the physiology of microcirculation and tissue metabolism. EG also binds a significant amount of plasma (estimated up to 1.7 liters), which is released during EG destruction and causes relative hemodilution. Isovolumic hemodilution is an established intraoperative procedure that serves to better control bleeding in procedures where bleeding is expected (e.g. cardiac surgery using an extracorporeal circuit or vascular surgery). However, partial hemodilution occurs even with standard IFT, and even when fluids are hardly given at all. Flow parameters in microcirculation have not yet been described depending on IFT conduction. The parameters of the microcirculation reflect its functioning, which will consequently affect the postoperative phase of the patient's moaning and clinical outcome. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Not yet recruiting |
NCT04982016 -
Effects of Fluid Therapy on Microcirculatory Reactivity
|
N/A | |
Recruiting |
NCT01204554 -
Microcirculation in Perforator Flaps. Enhancing Tissue Survival
|
Phase 0 | |
Completed |
NCT00810927 -
Role of Nitrogen Oxide (NO) in the Control of Choroidal Blood Flow During a Decrease in Ocular Perfusion Pressure
|
Phase 2 | |
Completed |
NCT04773899 -
COVID-19 Associated Endothelial Dysfunction Study
|
N/A | |
Completed |
NCT01024543 -
Role of Angiotensin II in Insulin-induced Microvascular Activity
|
N/A | |
Recruiting |
NCT05681052 -
Mottling Score and Central Venous Oxygen Saturation in Septic Shock Patients
|
||
Completed |
NCT02466594 -
Impact of Active Thermoregulation on the Microcirculation of Free Flaps
|
N/A | |
Completed |
NCT04500197 -
A Study of MIcrocirculatory Perfusion Alterations in Severe Burn Injury
|
||
Completed |
NCT04550026 -
Cardiovascular Effects of Heated Tobacco Products (HTP)
|
N/A | |
Recruiting |
NCT04294316 -
Enhanced-contrast Brain Ultrasound in Cardiorespiratory Arrest
|
N/A | |
Completed |
NCT03357523 -
Evaluation of Peripheral Microcirculation Hemodynamics Following Various Changes Based on Noninvasive Thermography
|
N/A | |
Terminated |
NCT04962048 -
The Influence of Pulse-synchronized Negative Pressure on the Dermal Microcirculation
|
N/A | |
Completed |
NCT02511899 -
Investigation of the Influence of Careless™, a Mangifera Indica Fruit Powder, on Microcirculation and Endothelial Function
|
N/A | |
Completed |
NCT02688946 -
Imaging Microcirculation and Gross Hemodynamics in Elective Colorectal Surgery
|
N/A | |
Completed |
NCT02549378 -
Study of the Impact of Changes in Carbonemia on Microcirculation in Patients Achieving a Test Hypercapnia
|
N/A | |
Completed |
NCT00335010 -
Intravenous NTG to Preserve Gastric Microcirculation During Gastric Tube Reconstruction
|
N/A | |
Active, not recruiting |
NCT04169204 -
Very Old Intensive Care Patients - Perfusion
|
||
Recruiting |
NCT04290767 -
Brain Ultrasound With Contrast Microbubbles Injection in Shock Status
|
N/A | |
Completed |
NCT03089814 -
Changes in Tissue Microcirculation During Ischemic Conditioning: Pilot Study
|
N/A | |
Completed |
NCT02705170 -
IMR Assessment in Patients With New Diagnosis of Left Ventricle Dilatation
|