Impact of Active Thermoregulation on the Microcirculation of Free Flaps

Status Completed

Clinical Trial Summary

This study evaluates the impact of active thermoregulation on free flap microcirculation following free flap transfer. Thermoregulation is performed by passive warming, active warming (water circulation based device) and active cooling. Changes in microcirculation are assessed using combined laser Doppler flowmetry and remission spectroscopy.

Clinical Trial Description

Measurements are conducted at the day of the operation as well as the first three days following the operation. Tissue temperature is assessed by a temperature measurement probe that is placed 8 mm underneath the skin. The microcirculation parameters of free perforator flaps are assessed using combined laser Doppler flowmetry and remission spectroscopy (O2C®). This allows non-invasive measurement of blood flow, capillary venous oxygen saturation and relative postcapillary filling pressure using a fiber optic probe that is placed on the flap surface. Controlled Thermoregulation (between 10 and 38°C) is enabled using a water circulation based system (Hilotherm Clinic®). ;

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02466594
Study type	Interventional
Source	Klinik Bogenhausen
Contact
Status	Completed
Phase	N/A
Start date	November 2013
Completion date	April 2015

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT04982016` - Effects of Fluid Therapy on Microcirculatory Reactivity	N/A
Recruiting	`NCT01204554` - Microcirculation in Perforator Flaps. Enhancing Tissue Survival	Phase 0
Completed	`NCT00810927` - Role of Nitrogen Oxide (NO) in the Control of Choroidal Blood Flow During a Decrease in Ocular Perfusion Pressure	Phase 2
Completed	`NCT04773899` - COVID-19 Associated Endothelial Dysfunction Study	N/A
Completed	`NCT01024543` - Role of Angiotensin II in Insulin-induced Microvascular Activity	N/A
Recruiting	`NCT05681052` - Mottling Score and Central Venous Oxygen Saturation in Septic Shock Patients
Recruiting	`NCT05606536` - The Impact of Intra-operative Fluid Infusion Rate on Microcirculation	N/A
Completed	`NCT04500197` - A Study of MIcrocirculatory Perfusion Alterations in Severe Burn Injury
Completed	`NCT04550026` - Cardiovascular Effects of Heated Tobacco Products (HTP)	N/A
Recruiting	`NCT04294316` - Enhanced-contrast Brain Ultrasound in Cardiorespiratory Arrest	N/A
Completed	`NCT03357523` - Evaluation of Peripheral Microcirculation Hemodynamics Following Various Changes Based on Noninvasive Thermography	N/A
Terminated	`NCT04962048` - The Influence of Pulse-synchronized Negative Pressure on the Dermal Microcirculation	N/A
Completed	`NCT02511899` - Investigation of the Influence of Careless™, a Mangifera Indica Fruit Powder, on Microcirculation and Endothelial Function	N/A
Completed	`NCT02688946` - Imaging Microcirculation and Gross Hemodynamics in Elective Colorectal Surgery	N/A
Completed	`NCT02549378` - Study of the Impact of Changes in Carbonemia on Microcirculation in Patients Achieving a Test Hypercapnia	N/A
Completed	`NCT00335010` - Intravenous NTG to Preserve Gastric Microcirculation During Gastric Tube Reconstruction	N/A
Active, not recruiting	`NCT04169204` - Very Old Intensive Care Patients - Perfusion
Recruiting	`NCT04290767` - Brain Ultrasound With Contrast Microbubbles Injection in Shock Status	N/A
Completed	`NCT03089814` - Changes in Tissue Microcirculation During Ischemic Conditioning: Pilot Study	N/A
Completed	`NCT02705170` - IMR Assessment in Patients With New Diagnosis of Left Ventricle Dilatation