Microcirculation Clinical Trial
Official title:
Study of the Impact of Changes in Carbonemia on Microcirculation in Patients - A Monocentric Study
The microcirculatory alterations is common in circulatory failure, especially during sepsis.
The severity of these changes and their sustainability are responsible of multi organ
failure and ultimately death. The optimization of microcirculatory flow could be a central
objective of the management of patients hospitalized in intensive care.
Microcirculation includes all blood vessels of a diameter smaller than 100 micrometer. It
represents the largest heat exchange surface of the body and is involved in tissue
oxygenation. Microcirculatory flow is conditioned by the macrocirculation (heart rate and
blood pressure) and the state of the microcirculation (thrombosis, vasoconstriction ...).
The role of the CO2 in regulating microcirculatory flow is little studied. A recent work of
our team and the oldest work in the literature lead to believe that CO2 has a specific role
in modulating microcirculatory flow. No study to date precisely studied the impact of
changes in the microcirculatory flow carbonemia .
The hypocapnia test is carried out in a standardized manner by inhalation of a mixture
enriched in CO2 7% allows a significant increase in carbonemia. Hypocapnia will in turn
obtained by a calibrated voluntary hyperventilation test.
Direct visualization of microcirculation by confocal microscopy is now considered the gold
standard for exploring the microcirculation.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT04982016 -
Effects of Fluid Therapy on Microcirculatory Reactivity
|
N/A | |
| Recruiting |
NCT01204554 -
Microcirculation in Perforator Flaps. Enhancing Tissue Survival
|
Phase 0 | |
| Completed |
NCT00810927 -
Role of Nitrogen Oxide (NO) in the Control of Choroidal Blood Flow During a Decrease in Ocular Perfusion Pressure
|
Phase 2 | |
| Completed |
NCT04773899 -
COVID-19 Associated Endothelial Dysfunction Study
|
N/A | |
| Completed |
NCT01024543 -
Role of Angiotensin II in Insulin-induced Microvascular Activity
|
N/A | |
| Recruiting |
NCT05681052 -
Mottling Score and Central Venous Oxygen Saturation in Septic Shock Patients
|
||
| Recruiting |
NCT05606536 -
The Impact of Intra-operative Fluid Infusion Rate on Microcirculation
|
N/A | |
| Completed |
NCT02466594 -
Impact of Active Thermoregulation on the Microcirculation of Free Flaps
|
N/A | |
| Completed |
NCT04500197 -
A Study of MIcrocirculatory Perfusion Alterations in Severe Burn Injury
|
||
| Completed |
NCT04550026 -
Cardiovascular Effects of Heated Tobacco Products (HTP)
|
N/A | |
| Recruiting |
NCT04294316 -
Enhanced-contrast Brain Ultrasound in Cardiorespiratory Arrest
|
N/A | |
| Completed |
NCT03357523 -
Evaluation of Peripheral Microcirculation Hemodynamics Following Various Changes Based on Noninvasive Thermography
|
N/A | |
| Terminated |
NCT04962048 -
The Influence of Pulse-synchronized Negative Pressure on the Dermal Microcirculation
|
N/A | |
| Completed |
NCT02511899 -
Investigation of the Influence of Careless™, a Mangifera Indica Fruit Powder, on Microcirculation and Endothelial Function
|
N/A | |
| Completed |
NCT02688946 -
Imaging Microcirculation and Gross Hemodynamics in Elective Colorectal Surgery
|
N/A | |
| Completed |
NCT00335010 -
Intravenous NTG to Preserve Gastric Microcirculation During Gastric Tube Reconstruction
|
N/A | |
| Active, not recruiting |
NCT04169204 -
Very Old Intensive Care Patients - Perfusion
|
||
| Recruiting |
NCT04290767 -
Brain Ultrasound With Contrast Microbubbles Injection in Shock Status
|
N/A | |
| Completed |
NCT03089814 -
Changes in Tissue Microcirculation During Ischemic Conditioning: Pilot Study
|
N/A | |
| Completed |
NCT02705170 -
IMR Assessment in Patients With New Diagnosis of Left Ventricle Dilatation
|