Microcirculation Clinical Trial
Official title:
Study of the Impact of Changes in Carbonemia on Microcirculation in Patients - A Monocentric Study
The microcirculatory alterations is common in circulatory failure, especially during sepsis.
The severity of these changes and their sustainability are responsible of multi organ
failure and ultimately death. The optimization of microcirculatory flow could be a central
objective of the management of patients hospitalized in intensive care.
Microcirculation includes all blood vessels of a diameter smaller than 100 micrometer. It
represents the largest heat exchange surface of the body and is involved in tissue
oxygenation. Microcirculatory flow is conditioned by the macrocirculation (heart rate and
blood pressure) and the state of the microcirculation (thrombosis, vasoconstriction ...).
The role of the CO2 in regulating microcirculatory flow is little studied. A recent work of
our team and the oldest work in the literature lead to believe that CO2 has a specific role
in modulating microcirculatory flow. No study to date precisely studied the impact of
changes in the microcirculatory flow carbonemia .
The hypocapnia test is carried out in a standardized manner by inhalation of a mixture
enriched in CO2 7% allows a significant increase in carbonemia. Hypocapnia will in turn
obtained by a calibrated voluntary hyperventilation test.
Direct visualization of microcirculation by confocal microscopy is now considered the gold
standard for exploring the microcirculation.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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