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Clinical Trial Summary

To learn if the study drug, YL-13027, is safe to give in combination with gemcitabine and nab-paclitaxel to participants with pancreatic cancer.


Clinical Trial Description

Primary Objectives 1. To determine the safety and tolerability of YL-13027 in combination with gemcitabine and nab-paclitaxel in participants with refractory metastatic pancreatic cancer. 2. To determine the objective response rate (ORR) of YL-13027 in combination with gemcitabine and nab-paclitaxel in participants with refractory metastatic pancreatic cancer. Secondary Objectives 1. To evaluate other indicators of the antitumor activity of YL-13027 in combination with gemcitabine and nab-paclitaxel. 2. To evaluate the PK of YL-13027 in combination with gemcitabine and nabpaclitaxel. Exploratory Objectives 1. To evaluate the PD effects of YL-13027 in combination with gemcitabine and nabpaclitaxel. 2. To evaluate biomarkers of response and resistance to YL-13027 in combination with gemcitabine and nab-paclitaxel. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06199466
Study type Interventional
Source M.D. Anderson Cancer Center
Contact Jordi Rodon Ahnert, MD
Phone (713) 792-5603
Email jrodon@mdanderson.org
Status Recruiting
Phase Phase 1
Start date January 22, 2024
Completion date January 30, 2027

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