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Metastases-directed Radiotherapy in Addition to Standard Systemic Therapy in Patients With Oligometastatic Breast Cancer — OLIGOMA  

Metastatic Breast Cancer Clinical Trial

Official title:
Effectiveness and Tolerability of Metastases-directed Radiotherapy in Addition to Standard Systemic Therapy in Patients With Oligometastatic Breast Cancer: A Randomized Controlled Multinational and Multicenter Clinical Trial

Clinical Trial Summary

The prognosis for patients with metastatic breast cancer has improved continuously. Systemic therapies alone are not able to cure the disease permanently. Investigators initiated this randomized controlled multinational and multicenter clinical trial to analyse the impact of a local metastases-directed radiotherapy in addition to standard systemic therapy in patients with oligometastatic breast cancer on progression-free survival and quality of life.

Clinical Trial Description

Preferably ablative radiotherapy (radiosurgery, stereotactic radiotherapy, hypofractionated image-guided radiotherapy (IGRT)) with few high-dose fractions. Larger lesions or lesions with critical normal tissue involvement should be treated with three-dimensional conformal radiation therapy (3D-CRT) or intensity-modulated radiation therapy (IMRT) in moderate hypofractionated radiotherapy (depending on the size and location of the target volume and the decision of the radiooncologist). For critical organs in the target volume, standard fractionated radiotherapy can be used. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04495309
Study type Interventional
Source University Hospital Schleswig-Holstein
Contact Kathrin Dellas, Professor
Phone 0431/500/26570
Email Kathrin.Dellas@uksh.de
Status Recruiting
Phase N/A
Start date March 5, 2021
Completion date June 30, 2025
View Details
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