Metastatic Breast Cancer Clinical Trial
Official title:
Determination of ESR1 Mutations by Digital PCR During Aromatase Inhibitor Treatment in Metastatic Breast Cancer
The purpose of the study is to determine the frequency ESR1 mutations by Digital PCR in patient with metastatic breast cancer.
Breast cancer is the most common cancer in woman. Aromatase inhibitors have demonstrated a
real efficacy however a resistance to treatment exists.
ESR1 mutations appear like involved in the mechanism of resistance to aromatase inhibitors
treatment.
The purpose of the study is to determine the frequency ESR1 mutations by Digital PCR in
patient with metastatic breast cancer.
The significance of the Digital PCR technique will be determined first in plasma issued from
healthy volunteers.
At the initiation of aromatase inhibitors treatment patient with metastatic breast cancer
will be included in the study. During their follow-up visit every 3 months), their status
towards their disease will be collected and a plasma will be collected too.
When the patient progress clinically or radiologically the plasma concomitant to this
progression will be analysed by Digital PCR to detect ESR1 mutations.
The patient will be followed during 2 years.
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