Metastatic Breast Cancer Clinical Trial
Official title:
The Study of Goserelin Plus Fulvestrant Comparing With Goserelin Plus Anastrozole for Advanced Breast Cancer
The purpose of this study is to assess the efficacy of goserelin plus fulvestrant 500mg comparing with goserelin plus anastrozole as first line endocrine therapy for pre- and perimenopausal HR+ advanced breast cancer.
Premenopausal advanced breast cancer patients who failed tamoxifen treatment are possible
good candidates for ovarian ablation/suppression and aromatase inhibitors.Fulvestrant has
been studied little in premenopausal women despite of its attractive mechanism of actions.
Based on this rationale, we introduced high-dose of fulvestrant with LHRH agonist as a
randomized trial comparing with AI plus LHRH agonist.
To assess efficacy of goserelin plus fulvestrant 500mg comparing with goserelin plus
anastrozole as first line endocrine therapy for pre- and perimenopausal HR+ advanced breast
cancer in terms of progression-free survival(PFS)
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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