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Clinical Trial Summary

This phase I/II study is designed to compare different treatment schedules of a personalized anti-cancer vaccine protocol which combines the cryoablation of a selected metastatic lesion with intra-tumor immunotherapy. The cryoablation causes the tumor to release tumor-specific antigens into the surrounding environment. The injection of bioengineered allogeneic immune cells, AlloStim(TM), into the lesion is designed to modulate the immune response and educate the immune system to kill other tumor cells.


Clinical Trial Description

The study will assess three different dosing schedules. A standard 3 plus 3 study design will be used. The starting dose for each dosing schedule will be escalated in subsequent groups of patients. The study will evaluate safety of increased frequency of AlloStim (TM) dosing and anti-tumor effect of the new proposed dose and frequency schedule. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02018419
Study type Interventional
Source Immunovative Therapies, Ltd.
Contact
Status Withdrawn
Phase Phase 1/Phase 2
Start date March 2014
Completion date March 2014

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