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Pilot Study Using Molecular Profiling to Find Potential Targets & Select Treatments for Pts With Met br ca — Side-Out  

Metastatic Breast Cancer Clinical Trial

Official title:
A Pilot Study Utilizing Molecular Profiling by IHC, FISH, DNA Microarray, and Reverse Phase Protein Microarray (RPMA) of Patients' Tumors to Find Potential Targets and Select Treatments for Patients With Metastatic Breast Cancer.

Clinical Trial Summary

The purpose of this study is to determine the response rate, that is the % of patients with non-progression of their metastatic breast cancer after 4 months on treatment that was selected by molecular testing and proteomics.

Clinical Trial Description

To determine the percent of patients with refractory breast cancer where molecular profiling and RPMA-based protein pathway activation analysis of their tumor, can change the clinical course of their disease (i.e. produce a Growth Modulation Index (GMI) ≥1.3). The GMI is calculated as the ratio of Progression-free survival (PFS) under molecular profiling and RPMA analysis selected treatment to the time to progression (TTP) for the most recent regimen the patient has progressed on. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01074814
Study type Interventional
Source Translational Drug Development
Contact
Status Completed
Phase Early Phase 1
Start date March 2010
Completion date July 2012
View Details
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