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Clinical Trial Summary

CHANCES-IPC 2021-008 is First In Human, Phase I, multicenter, European study evaluating an anti-CD73, IPH5301 in advanced and/or metastatic cancer. The trial will be conducted in two parts, Part I- Dose escalation: This part aims to identify the maximum tolerated dose (MTD) of IPH5301 agent in monotherapy and recommended phase 2 dose (RP2D) for future trials, followed by a safety expansion study part cohort. Part II- Expansion cohort: A total of 12 HER2+ cancer patients, respectively 6 breast cancer patients and 6 gastric cancer patients, is planned to be enrolled into the next expansion cohort to select a recommended dose of IPH5301 to be administered in combination with chemotherapy and trastuzumab for evaluation in future trials with selected advanced solid tumors.


Clinical Trial Description

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Study Design


Related Conditions & MeSH terms


NCT number NCT05143970
Study type Interventional
Source Institut Paoli-Calmettes
Contact DOMINIQUE GENRE
Phone 0491223778
Email drci.up@ipc.unicancer.fr
Status Recruiting
Phase Phase 1
Start date January 21, 2022
Completion date February 2026

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