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Metabolism clinical trials

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NCT ID: NCT04178694 Completed - Metabolism Clinical Trials

The Influence of Non-invasive Ventilation on Metabolism in Healthy Volunteers

Ganesh
Start date: January 1, 2020
Phase: N/A
Study type: Interventional

Before inclusion in the trial. Careful medical history and medication use will be asked. Once included, 5 healthy subjects non-invasive ventilation(V60, Philips, Eindhoven, The Netherlands) will be administered at a level of positive end expiratory pressure (PEEP) of 4 cmH2O and without additional inspiratory support. Inspiratory support will then increase by 2 cmH2O every 2 minutes until 8 cmH2O is achieved for 2 minutes. The energy expenditure is measured using indirect calorimetry (Q-NRG®, Cosmed, Italy). To measure respiratory effort, the reversed RPE-scale was created for the purpose of the study. It uses the validated "rate of perceived exertion" scale (RPE-scale) which was altered by adding a reversed part. This could result in a score of -10 (no respiratory effort) until +10 ( maximal respiratory effort) where 0 represents the basal respiratory condition. Monitoring of heart rate, blood pressure and cardiac output will be done ( Nexfin®, BMEYE, Amsterdam, The Netherlands). After termination of the study clinical observation by principal investigator or co-investigator will be done for 15 minutes or until all side effects have worn off. If no side effects are observed, subjects will be released.

NCT ID: NCT04178681 Recruiting - Nutrition Clinical Trials

Postprandial Effects of Milk Fats

POEMI
Start date: December 2, 2019
Phase: N/A
Study type: Interventional

Nowadays, mostly vegetable fat blends are used in infant formula, but the use of bovine milk fat is increasing. In terms of fat structure, bovine milk fat and vegetable fats differ. Bovine milk fat has a higher percentage of palmitic acid attached to the sn-2 position of the glycerol backbone compared to vegetable fat blend. Also bovine milk fat contains milk fat globular membranes, as opposed to vegetable fat. With this study the investigators want to examine the effects of a vegetable fat blend versus bovine milk fat without globular membranes and bovine milk fat with globular membranes on underlying mechanistic, immune and metabolic responses.

NCT ID: NCT04144426 Completed - Metabolism Clinical Trials

Meal Schedule Effects on Circadian Energy Balance in Adults

Start date: October 8, 2015
Phase: N/A
Study type: Interventional

This study will test will how eating on a particular daily schedule may effect energy, weight gain or loss, and body temperature.

NCT ID: NCT04078646 Completed - Metabolism Clinical Trials

Influence of Proteins on the Bioavailability of Carotenoids

CAROPROT
Start date: October 11, 2019
Phase: N/A
Study type: Interventional

A postprandial intervention study is conducted on healthy male subjects to evaluate whether the addition of proteins (why protein isolate, soy protein) can help to increase the bioavailability of carotenoids from a tomato/carrot beverage.

NCT ID: NCT04055428 Recruiting - Clinical trials for Cardiovascular Diseases

NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals

Start date: August 15, 2020
Phase: Phase 2
Study type: Interventional

Black individuals are more likely to have decreased insulin sensitivity which results in a high risk for the development of cardiometabolic disease. The reasons for this are incompletely understood. Natriuretic peptides (NPs) are hormones produced by the heart that play a role in regulating the metabolic health of an individual. Low circulating level of NPs is an important contributor to increased risk for diabetes. The NP levels are relatively lower among Black individuals thus affecting their metabolic health and putting them at a higher risk for diabetes. This study aims to test the hypothesis that by augmenting NP levels using sacubitril/valsartan, among Black Individuals one can improve their metabolic health (as measured by insulin sensitivity & energy expenditure) and help establish the role of NPs in the underlying mechanism behind increased risk for cardiometabolic disease in these population.

NCT ID: NCT04025346 Completed - Metabolism Clinical Trials

To Evaluate the Efficacy of Capsimax on Metabolic Rate

Start date: October 17, 2019
Phase: N/A
Study type: Interventional

Capsimax™ is a proprietary Capsicum Extract that employs Beadlet Technology. In the previous study it has been used to investigate its effect in reducing body fat/weight and increase metabolic rate. In this study, Capsimax™ will be used to assess effect on Resting Energy Expenditure (REE) using Indirect Calorimetry.

NCT ID: NCT04013607 Completed - Metabolism Clinical Trials

Fiber Fermentation Kinetics Inside the Gut, and Utilization of Bacterial Metabolites

Start date: July 8, 2019
Phase: N/A
Study type: Interventional

In this study, the life course of SCFA and their regulatory role in human metabolism will be traced using a nose-intestine catheter. The investigators have methodological questions: investigate the envisioned kinetic profiles of stable isotope tracers of SCFAs, and to establish the time points of plasma sampling (to determine systemic availability of SCFAs). The resulting timepoints established in this pilot study will be applied during a future human intervention study.

NCT ID: NCT03983733 Completed - Healthy Clinical Trials

PREDICT 2: Personalized Responses to Dietary Composition Trial 2

Start date: June 10, 2019
Phase: N/A
Study type: Interventional

Foods in the human diet can affect the development of diseases over time, such as diabetes or heart disease. This is because the amount and types of foods in the diet eat can affect a person's weight, and because different foods are metabolised (processed) by the body in different ways. Scientists have also found that the bacteria in the human gut (the gut microbiome) affect their metabolism, weight and health and that, together with a person's diet and metabolism, could be used to predict appetite and how meals affect the levels of sugar (glucose) and fats (lipids) found in blood after eating. If blood sugar and fat are too high too often for too long, there is a greater chance of developing diseases such as diabetes and cardiovascular disease. The gut microbiome is different in different people. Only 10-20% of the types of bacteria found in the human gut are found in everyone. This might mean that the best diet to prevent disease needs matching to a person's gut microbiome and it might be possible to find personalised foods or diets that will help reduce the chance of developing chronic disease as well as metabolic syndrome. The study investigators are recruiting volunteers aged 18-70 years to take part in a study that aims to answer the questions above. Participants will be asked to consume standardised meals on up to 8 days while wearing glucose monitors (Abbott Freestyle Libre) to measure their blood sugar levels. Participants will also be required to prick their fingers at regular intervals to collect small amounts of blood, and to record their appetite, food, physical activity and sleep using apps and wearable devices. They will be asked to collect a fecal and saliva sample before consuming the standardised meals, and to provide a fasted blood sample at the end of the study period.

NCT ID: NCT03916263 Completed - Diet Modification Clinical Trials

Low Starch Dietary Education Program vs. Traditional Treatment for PCOS

Start date: August 29, 2018
Phase: Early Phase 1
Study type: Interventional

Compare weight loss and metabolic parameters in patients using a low starch dietary education program vs. traditional treatment (i.e., prescribing metformin, low calorie diet and exercise) for health improvement in women with PCOS.

NCT ID: NCT03897023 Recruiting - Microbiota Clinical Trials

Gut Microbiota Pilot Study

Start date: April 15, 2019
Phase:
Study type: Observational

Microbiota is known to effect metabolism. This is pilot study to get status of microbiota from normal control. It will be compared to data from specific patients in ICU via further study.