The Effect of Sitting and Moderate Exercise on Plasma Triglyceride Elevation After a Meal

Metabolic Syndrome Clinical Trial

Official title:

The Effect of Sitting and Moderate Exercise on Plasma Triglyceride Elevation After a Meal

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03098446
• Other study ID #: 2016-12-0022
• Status: Completed
• Phase: N/A
• Start date: April 8, 2017
• Est. completion date: August 11, 2017

Study information

• Verified date: October 2018
• Source: University of Texas at Austin
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to investigate the effect of 4 days of sitting and moderate exercise on plasma triglyceride elevation after a meal.

Description:

Subjects will undergo three weeks (two intervention, one washout) of testing during which they will participate in two conditions: 1) prolonged sitting (~14-hours/day) with a 1-hour bout of acute exercise at 65% of pre-intervention VO2max and 2) prolonged sitting (~14-hours/day) without an acute bout of exercise. During each intervention week, subjects will have 2 days of dietary and activity control, followed by 4 days during which prolonged sitting will occur. On the evening of the 4th day, subjects in the exercise group will perform the acute bout of exercise. On day 5, all subjects will undergo a lipid tolerance test to determine the body's ability to clear triglycerides from the blood as well as insulin/glucose response and substrate oxidation. Blood samples will be assayed for the previously mentioned substances and postprandial gas collection will be analyzed via indirect calorimetry.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: August 11, 2017
• Est. primary completion date: August 11, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

Exclusion Criteria:

• cardiovascular problems (e.g. pre-existing heart issues, coronary artery disease, hypertension, etc.)

• respiratory problems

• musculoskeletal problems that prevent prolonged sitting or exercise

• obesity

• susceptibility to fainting

Related Conditions & MeSH terms

• Atherosclerosis
• Metabolic Syndrome
• Metabolic Syndrome X

Intervention

Behavioral:
• Prolonged sitting with exercise
Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trial. Following this 2-day period, they will undergo the prolonged sitting trial with the acute bout of exercise on day 4. Day 5 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.
• Prolonged sitting without exercise
Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trial. Following this 2-day period, they will undergo the prolonged sitting trial, but will not be asked to complete an acute bout of exercise on day 4. Day 5 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.

Locations

Country	Name	City	State
United States	University of Texas at Austin Human Performance Laboratory	Austin	Texas

Sponsors (1)

Lead Sponsor	Collaborator
University of Texas at Austin

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Plasma Triglycerides	Areas under the curve for triglyceride concentration will be calculated for hourly samples from a 6-hour lipid tolerance test	6-hours
Secondary	Plasma Insulin	Areas under the curve for insulin concentration will be calculated for hourly samples from a 6-hour lipid tolerance test	6-hours
Secondary	Plasma Glucose	Areas under the curve for glucose concentration will be calculated for hourly samples from a 6-hour lipid tolerance test	6-hours