Exercise Training and Metabolic Syndrome

Metabolic Syndrome Clinical Trial

Official title:

Effects of Aerobic Interval Training on Clinical Biomarkers and Quality of Life in Metabolic Syndrome

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03036332
• Other study ID #: RATMiranda1
• Status: Completed
• Phase: N/A
• First received: January 26, 2017
• Last updated: January 27, 2017
• Start date: June 1, 2015
• Est. completion date: December 10, 2016

Study information

• Verified date: January 2017
• Source: Universidade Estadual Paulista Júlio de Mesquita Filho
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The present study aimed to determine the effects of 16 weeks of aerobic interval training on quality of life and a set of clinical biomarkers.

Description:

Besides the traditional metabolic syndrome risk factors (dyslipidemia, raised blood pressure, central obesity and dysglycemia) subclinical disorders related to chronic inflammation and cell damage have been reported on metabolic syndrome. Therefore, regarding the systemic feature of metabolic syndrome, we investigated an new approach of aerobic interval training on several clinical biomarkers widely used. Such training used differs from current aerobic protocols in order to attenuate metabolic and musculoskeletal overload on untrained and unhealthy subjects.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 53
• Est. completion date: December 10, 2016
• Est. primary completion date: December 10, 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 35 Years to 60 Years

Eligibility

Inclusion Criteria:

• Having metabolic syndrome according to international diabetes foundations definition (IDF).

• Age between 35 - 60 years and untrained subjects.

Exclusion Criteria:

• Musculotendinous or osteoarticular injuries in the lower limbs and/or spine

• Chronic pulmonary diseases

• Neurological disorders

• Kidney failure

• High-risk cardiovascular diseases (Unstable angina pectoris, Uncompensated heart failure, complex ventricular arrhythmias or myocardial infarction during the last month).

Related Conditions & MeSH terms

• Metabolic Syndrome
• Metabolic Syndrome X
• Syndrome

Intervention

Behavioral:
• Aerobic interval training
Carried out 3 times per week for 16 weeks

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Universidade Estadual Paulista Júlio de Mesquita Filho

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Pro-inflammatory marker	Serum levels of C-reactive protein	16 weeks
Secondary	Quality of life	The Medical Outcomes Study-Short Form 36 (SF-36)	16 weeks
Secondary	A set of clinical biomarkers	Serum levels lof Homocysteine; Creatinine, Creatine kinase (ck); creatine kinase MB (ck-mb); Troponin t; aspartate aminotransferase; alanine aminotransferase; and complete blood count.	16 weeks