Metabolic Syndrome Clinical Trial
Official title:
Effects of Canola Oil on Vascular and Metabolic Parameters in Individuals With Metabolic Syndrome
MetS is an early stage of CVD and is an appropriate target for dietary interventions. MetS
is a clustering of risk factors (abdominal obesity, elevated serum triglycerides, low
HDL-cholesterol, hypertension, elevated fasting blood glucose) accompanied by low grade
chronic inflammation, hepatic steatosis (fatty liver) and reduced vascular function.
This study will investigate the effect of a 12 week intervention with canola oil versus the
typical fat mixture in the Western diet on blood lipids, blood vessel function and MetS
parameters. CVD risk will be assessed based on the profile of lipids and other factors in
the blood as well using specialized equipment for non-invasive monitoring of blood vessel
function.
The current, worldwide obesity epidemic is significantly increasing the number of
individuals with Metabolic Syndrome (MetS), an early stage combination of risk factors which
predisposes individuals to cardiovascular disease (CVD) and other chronic diseases. While it
has been shown that modification of dietary fat intake can play an important role in
prevention and management of CVD there is an absence of dietary intervention studies
focusing on dietary oils and early stage modification of MetS components, particularly those
affecting progression to CVD.
The composition of canola oil is considered healthy. However, there is a lack of
scientifically sound clinical studies directly comparing canola oil with other fats in the
diet. Given that much of the evidence for current dietary recommendations for type and
amounts of fatty acids is based on heart disease, the proposed research will contribute to
the knowledge base for dietary fat recommendations for individuals with MetS.
Specifically, this study will investigate the effect of a 12 week intervention with canola
oil versus the typical fat mixture in the Western diet on blood lipids, blood vessel
function and MetS parameters. CVD risk will be assessed based on the profile of lipids and
other factors in the blood as well using specialized equipment for non-invasive monitoring
of blood vessel function.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator)
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