Metabolic Syndrome Clinical Trial
— URICOfficial title:
The Influence of Antiphospholipid Antibodies on the Relationship Between Hyperurecemia, Gout and Metabolic Syndrome
NCT number | NCT01818505 |
Other study ID # | URIC |
Secondary ID | |
Status | Recruiting |
Phase | N/A |
First received | March 21, 2013 |
Last updated | April 11, 2014 |
Start date | March 2013 |
Patients with hyperuricemia were confirmed to have higher risks of cardiovascular disease, but the exact mechanism remained to be elucidated. Many connective tissue diseases such as rheumatoid arthritis are often associated with antiphospholipid antibodies-associated endothelial impairment. In the present study, the investigators will analyze the presence of antiphospholipid antibodies in the serum of the patients with gout/asymptomatic hyperuricemia, with a comparison to the patients of osteoarthritis but without hyperuricemia and gout. The investigators expect to find a correlation between these pathogenic antibody and those cardiovascular co-morbidities.
Status | Recruiting |
Enrollment | 210 |
Est. completion date | |
Est. primary completion date | December 2015 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 20 Years and older |
Eligibility |
Inclusion Criteria: 1. Patient with gouty arthritis 2. Patient with asymptomatic hyperurecemia 3. Patient of osteoarthritis but without hyperuricemia and gout Exclusion Criteria: 1.Patient younger than 20 y/o. |
Observational Model: Case Control, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Taiwan | National Taiwan University Hospital Yun-Lin Branch | Dou-Liou City | Yun-Lin County |
Lead Sponsor | Collaborator |
---|---|
National Taiwan University Hospital |
Taiwan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | development of metabolic syndrome or cardiovascular events | 36 months | No | |
Secondary | Acute myocardial infarct or stroke | 36 months or more | No |
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