Metabolic Syndrome Clinical Trial
Official title:
The Influence of Antiphospholipid Antibodies on the Relationship Between Hyperurecemia, Gout and Metabolic Syndrome
Patients with hyperuricemia were confirmed to have higher risks of cardiovascular disease, but the exact mechanism remained to be elucidated. Many connective tissue diseases such as rheumatoid arthritis are often associated with antiphospholipid antibodies-associated endothelial impairment. In the present study, the investigators will analyze the presence of antiphospholipid antibodies in the serum of the patients with gout/asymptomatic hyperuricemia, with a comparison to the patients of osteoarthritis but without hyperuricemia and gout. The investigators expect to find a correlation between these pathogenic antibody and those cardiovascular co-morbidities.
Patients with hyperuricemia were confirmed to have higher risks of cardiovascular disease,
but the exact mechanism remained to be elucidated. Many connective tissue diseases such as
rheumatoid arthritis are often associated with antiphospholipid antibodies-associated
endothelial impairment. In the present study, we'll analyze the presence of antiphospholipid
antibodies in the serum of the patients with gout/ asymptomatic hyperuricemia, with a
comparison to the patients of osteoarthritis but without hyperuricemia and gout. We expect
to find a correlation between these pathogenic antibody and those cardiovascular
co-morbidities.
Patient eligibility：
1. Patients with gout
2. Patients with asymptomatic hyperuricemia
3. Patients of osteoarthritis but without hyperuricemia and gout Exclusion Criteria：
Patients younger than 20 years old
;
Observational Model: Case Control, Time Perspective: Prospective
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