Metabolic Syndrome Clinical Trial
Official title:
Exercise, Statins, and the Metabolic Syndrome
Here we tested if statins or exercise plus statins had a greater capacity to lower metabolic syndrome risk factors in sedentary individuals with at least 2 metabolic syndrome risk factors. We also examined if statins impacted exercise response for mitochondrial content in muscle or aerobic fitness.
OBJECTIVES: Determine if simvastatin impairs exercise training adaptations.
BACKGROUND: Statins are commonly prescribed in combination with therapeutic lifestyle
changes, including exercise, to reduce cardiovascular disease risk in patients with the
metabolic syndrome. Statin use has been linked to skeletal muscle myopathy and impaired
mitochondrial function, but it is unclear whether statin use alters adaptations to exercise
training.
METHODS: We examined the effects of simvastatin on changes in cardiorespiratory fitness and
skeletal muscle mitochondrial content in response to aerobic exercise training. Sedentary
overweight or obese adults with at least 2 metabolic syndrome risk factors (defined
according to National Cholesterol Education Panel Adult Treatment Panel III criteria) were
randomized to 12 weeks of aerobic exercise training or to exercise in combination with
simvastatin (40 mg per day). The primary outcomes were cardiorespiratory fitness and
skeletal muscle (vastus lateralis) mitochondrial content (citrate synthase enzyme activity).
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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