Outcome
Type |
Measure |
Description |
Time frame |
Safety issue |
Primary |
Cognitive Test Results regarding attention and processing speed |
How do cognitive test results regarding attention and processing speed measured by TMT-A vary between individuals with MDD/SED and HC? |
At baseline, i.e. at diagnosis, at first study-specific follow-up (12 months from baseline), and at second study-specific follow-up (24 months from baseline) |
|
Primary |
Cognitive Test Results regarding attention and processing speed |
How do cognitive test results regarding attention and processing speed measured by TMT-B vary between individuals with MDD/SED and HC? |
At baseline, i.e. at diagnosis, at first study-specific follow-up (12 months from baseline), and at second study-specific follow-up (24 months from baseline) |
|
Primary |
Cognitive Test Results regarding attention and processing speed |
How do cognitive test results regarding attention and processing speed measured by SDPTvary between individuals with MDD/SED and HC? |
At baseline, i.e. at diagnosis, at first study-specific follow-up (12 months from baseline), and at second study-specific follow-up (24 months from baseline) |
|
Primary |
Cognitive Test Results regarding attention and processing speed |
How do cognitive test results regarding attention and processing speed measured by Reaction Time Test Simple vary between individuals with MDD/SED and HC? |
At baseline, i.e. at diagnosis, at first study-specific follow-up (12 months from baseline), and at second study-specific follow-up (24 months from baseline) |
|
Primary |
Cognitive Test Results regarding memory |
How do cognitive test results regarding memory, measured by Corsi Span forward and backward, vary between individuals with MDD/SED and HC? |
At baseline, i.e. at diagnosis, at first study-specific follow-up (12 months from baseline), and at second study-specific follow-up (24 months from baseline) |
|
Primary |
Cognitive Test Results regarding memory |
How do cognitive test results regarding memory, measured by RAVLT Learning and Recall vary between individuals with MDD/SED and HC? |
At baseline, i.e. at diagnosis, at first study-specific follow-up (12 months from baseline), and at second study-specific follow-up (24 months from baseline) |
|
Primary |
Cognitive Test Results regarding executive function |
How do cognitive test results regarding executive functions, measured by TMT-B, vary between individuals with MDD/SED and HC? |
At baseline, i.e. at diagnosis, at first study-specific follow-up (12 months from baseline), and at second study-specific follow-up (24 months from baseline) |
|
Primary |
Cognitive Test Results regarding executive function |
How do cognitive test results regarding executive functions, measured by Reaction Time Test Complex (or CPT) vary between individuals with MDD/SED and HC? |
At baseline, i.e. at diagnosis, at first study-specific follow-up (12 months from baseline), and at second study-specific follow-up (24 months from baseline) |
|
Primary |
Cognitive Test Results regarding executive function |
How do cognitive test results regarding executive functions, measured by Stroop Test vary between individuals with MDD/SED and HC? |
At baseline, i.e. at diagnosis, at first study-specific follow-up (12 months from baseline), and at second study-specific follow-up (24 months from baseline) |
|
Primary |
Cognitive Test Results regarding language |
How do cognitive test results regarding language, measured by FAS vary between individuals with MDD/SED and HC? |
At baseline, i.e. at diagnosis, at first study-specific follow-up (12 months from baseline), and at second study-specific follow-up (24 months from baseline) |
|
Primary |
Cognitive Test Results regarding language |
How do cognitive test results regarding language, measured by Boston Naming Test vary between individuals with MDD/SED and HC? |
At baseline, i.e. at diagnosis, at first study-specific follow-up (12 months from baseline), and at second study-specific follow-up (24 months from baseline) |
|
Primary |
Cognitive Test Results regarding visuospatial capacity |
How do cognitive test results regarding visuospatial capacity measured by: Cube Copying Test, vary between individuals with MDD/SED and HC? |
At baseline, i.e. at diagnosis, at first study-specific follow-up (12 months from baseline), and at second study-specific follow-up (24 months from baseline) |
|
Secondary |
MRI features, measured by morphological and quantitative MR sequences of the brain |
How do morphological as well as quantitative MR sequences, with and without intravenous contrast agent with following vary between individuals with MDD/SED and HC? |
At baseline, i.e. at diagnosis, at first study-specific follow-up (12 months from baseline), and at second study-specific follow-up (24 months from baseline) |
|
Secondary |
Biochemical Profile in blood regarding inflammation, stress and neurodegeneration |
How the biochemical profile in blood vary between individuals with MDD/SED and HC? |
At baseline, i.e. at diagnosis, at first study-specific follow-up (12 months from baseline), and at second study-specific follow-up (24 months from baseline) |
|
Secondary |
Biochemical Profile in saliva regarding inflammation and stress |
How the biochemical profile in saliva as described above vary between individuals with MDD/SED and HC? |
At baseline, i.e. at diagnosis, at first study-specific follow-up (12 months from baseline), and at second study-specific follow-up (24 months from baseline) |
|
Secondary |
Biochemical Profile in hair regarding exposure to stress |
How the biochemical profile in hair as described above vary between individuals with MDD/SED and HC? |
At baseline, i.e. at diagnosis, at first study-specific follow-up (12 months from baseline), and at second study-specific follow-up (24 months from baseline) |
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