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Microbiome and the Gut-Brain Axis

Mental Disorder Clinical Trial

Official title:
Microbiome and the Gut-Brain Axis

Clinical Trial Summary

This research study will examine the relationship interconnecting medical body health, mental health, and microbes of the digestive tract in persons living with serious mental illnesses,as compared to persons without such disorders. Existing research suggests that interactions between digestive tract microbes and the body may influence brain function circuits, mood, anxiety state, cognition, behavior, and medical physiology.

Clinical Trial Description

People living with serious mental illnesses have far shorter life expectancy due to various attending medical disorders. Vast knowledge gaps exist regarding microbial taxa responsible for governing various the human states of health or morbidity or interactions with medications. Serious mental illnesses collectively comprise the single largest medical category of life-long disability worldwide. Mounting evidence in humans and in animal models of schizophrenia, post-traumatic stress disorder (PTSD) and related mental illnesses point to gut microbiome-host interactions that may influence brain function circuits, mood, anxiety state, cognition, behavior, as well as generate medical comorbidities. This research study will collect stool samples and blood for in vitro analysis of microbiome and metabolomics. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02693327
Study type Observational
Source University of Florida
Contact
Status Completed
Phase
Start date April 2016
Completion date September 2017
View Details
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