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Menopause, Premature clinical trials

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NCT ID: NCT05737329 Active, not recruiting - Clinical trials for Primary Ovarian Insufficiency

Efficacy, Safety, and Tolerability of Higher Doses Estrogen Therapy in Women With Premature Ovarian Insufficiency

Start date: March 1, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

The goal of this study is to assess the effects of higher doses versus standard hormone therapy on quality of life (QoL), symptoms due to estrogen deficiency, and bone health in women with premature ovarian insufficiency (POI). The efficacy of the hormonal treatment will be assessed clinically and also by measuring serum concentrations of Estradiol (E2), Follicle-Stimulating Hormone (FSH), Luteinizing hormone (LH), total Testosterone (T), Estrone (E1), E1 sulfate (E1S), and Sex Hormone Binding Globulin (SHBG). Bone mineral density (BMD) will be measured using dual-energy X-ray absorptiometry. Safety will be assessed by measuring endometrial thickness with Gynecological transvaginal ultrasound (TVS), treatment-related adverse events (AEs) and treatment-emergent AEs monitoring.

NCT ID: NCT04675970 Active, not recruiting - Clinical trials for Premature Ovarian Failure

Long Term Follow up Patients With Premature Ovarian Failure ex Vivo Gene Therapy

UB-OVF
Start date: September 1, 2020
Phase:
Study type: Observational

This is a multi-centers of long term safety and efficacy follow up study for patients with premature ovarian failure (the women aged younger than 40 years, who present with amenorrhoea, hypergonadotropic hypogonadism, and infertility) who have been treated with ex vivo gene therapy drug product in Institute of Bio-Stem Cell Rehabilitation UAB - sponsored clinical studies. After completing the parent clinical study (approximately 6 month), eligible subject will be followed for additional 2 years for total of 2 years and 6 month post drug product infusion. No investigation drug product will be administered in the study

NCT ID: NCT04381299 Active, not recruiting - Infertility Clinical Trials

Will Autologous Platelet Rich Plasma Able To Restore Ovarian Function?

Start date: April 25, 2021
Phase:
Study type: Observational

A-PRP (Autologous Platelet Rich Plasma) is becoming widely used in a variety of medical procedures seeking tissue remodeling and/or healing as an intervention. To date, applications in orthopedics, wound healing, dermatology and plastic surgery have gained general acceptance, primarily as the role of platelets and their activation in tissue repair and recovery has become better understood at a cellular and molecular level. This study will involve adult women with a diagnosis of Premature ovarian insufficiency (POI) willing to perform an IVF/ICSI treatment.

NCT ID: NCT03877471 Active, not recruiting - Clinical trials for Primary Ovarian Insufficiency

Mesenchymal Stem Cells (MSCs) - Like Cell Transplantation in Women With Primary Ovarian Insufficiency

MSCLCTWPOI
Start date: April 3, 2019
Phase: Phase 1
Study type: Interventional

There is a high incidence of women suffering from Primary Ovarian Insufficiency (POI). So far, there was no treatment sufficient enough to cure POI. Cell therapy is a rapidly developing field and have shown immense promise in the treatment of ovarian dysfunction. In this study, the investigator will evaluate the safety of MSC-like cell therapy in women suffering from POI.

NCT ID: NCT03381300 Active, not recruiting - Turner Syndrome Clinical Trials

Preservation of Ovarian Cortex Tissue in Girls With Turner Syndrome

Start date: January 1, 2018
Phase: N/A
Study type: Interventional

Rationale: Infertility due is a major concern for girls with Turner syndrome (TS) and their parents. Physicians are often asked about possible options to preserve their fertility. However, despite some experimental case reports, clear evidence for fertility preservation in these girls is lacking and many questions remain. Without evidence on the effectiveness of fertility preservation it cannot routinely be offered to girls with TS. Objective: To investigate the occurrence of live birth in women with TS after ovarian tissue cryopreservation in childhood followed by auto transplantation in adulthood. Study design: A national multicentre exploratory intervention study Study population: Girls diagnosed with Turner Syndrome, aged 2-18 years. Intervention: Ovarian tissue cryopreservation in childhood followed by auto transplantation in adulthood. In order to obtain the ovarian tissue for cryopreservation, all girls must undergo a laparoscopy under general anaesthesia which will be performed in academic/university clinics with paediatric surgery. During the laparoscopic intervention, a unilateral oophorectomy will be performed, thereby leaving the other ovary intact for hormone production, ovulation, spontaneous pregnancies and as an auto transplantation site for cryopreserved-thawed ovarian cortical tissue later on. Furthermore, a small sample of the ovarian cortex will be used to assess the oocyte quality and genetics (e.g. the presence of germ line mosaicism). Oocytes will be karyotyped by using Fluorescence in situ hybridization (FISH). Karyotypic and hormonal data will be collected once at the yearly clinical visit at the paediatric-endocrinologist. Therefore, a buccal swab and one extra blood sample will be taken and evaluated during the routine laboratory evaluation. In the future, auto transplantation of frozen-thawed ovarian cortex strips will be performed.

NCT ID: NCT03069209 Active, not recruiting - Clinical trials for Premature Ovarian Failure

Autologous Bone Marrow-Derived Stem Cell Transplantation in Patients With Premature Ovarian Failure (POF)

Start date: January 2015
Phase: Phase 1/Phase 2
Study type: Interventional

This is an open label, single arm, single center investigation to assess the safety and efficacy of purified adult autologous bone marrow derived specific populations of stem cells and mesenchymal stem cells injected into the ovaries (intraovarian injection), through a 12 week follow-up period. The investigators' chosen model of study is based on increasing the efficiency of the approach by choosing an autologous model which preserves the genetic composition of an individual that is vital in infertility conditions. Additionally the approach involves transplanting a combination of specific purified stem cell types which all aid in ovarian function recovery.

NCT ID: NCT02795000 Active, not recruiting - Clinical trials for Primary Ovarian Insufficiency

Development a Predictive Nomogram for Primary Ovarian Insufficiency

Start date: October 2016
Phase:
Study type: Observational

The purpose of this research is to develop a predictive nomogram for primary ovarian insufficiency.

NCT ID: NCT02467231 Active, not recruiting - Clinical trials for Premature Ovarian Failure

Ovarian Reserve After Cancer: Longitudinal Effects

ORACLE
Start date: February 2009
Phase:
Study type: Observational

Women of reproductive age who will receive treatment for cancer that includes chemotherapy may participate in a study measuring ovarian function over time. Eligible women are asked to complete a questionnaire, a menstrual diary, a brief physical examination, an ultrasound, and a blood test before, during and after cancer treatment.

NCT ID: NCT00619333 Active, not recruiting - Clinical trials for Premature Ovarian Failure

Inactive FSH in Galactosemia

Start date: March 2007
Phase: N/A
Study type: Interventional

The aim of the study is to investigate whether inactive FSH plays a role in the development of Premature Ovarian Failure in women with Classic Galactosemia