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Clinical Trial Summary

Adult patients with r/r acute lymphoblastic leukemia (ALL) (stratum I), r/r Non-Hodgkin's lymphoma (NHL) including chronic lymphocytic leukaemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) or mantle cell lymphoma (MCL) (stratum II) as well as paediatric patients with r/r ALL (stratum III) will be treated with autologous T-lymphocytes transduced by the third-generation RV-SFG.CD19.CD28.4-1BBzeta retroviral vector. The main purpose of this study is to evaluate safety and feasibility of escalating CD19.CAR T cell doses (0,1-20×20^7 transduced cells/m^2) after lymphodepletion with fludarabine and cyclophosphamide.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03676504
Study type Interventional
Source University Hospital Heidelberg
Contact Prof. Dr. Michael Schmitt
Phone +49-6221-566614
Email michael.schmitt@med.uni-heidelberg.de
Status Recruiting
Phase Phase 1/Phase 2
Start date September 7, 2018
Completion date April 1, 2024

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