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Identifying and Caring for Individuals With Inherited Cancer Syndrome

Malignant Solid Neoplasm Clinical Trial

Official title:
Approaches to Identify and Care for Individuals With Inherited Cancer Syndromes

Clinical Trial Summary

This trial examines approaches to identify and care for individuals with inherited cancer syndrome. The purpose of this study is to offer no cost genetic testing to the general public. Researchers hope to learn the value of providing broad, public-wide testing for high risk cancer types (like hereditary breast and ovarian cancer or Lynch syndromes) instead of only testing people whose families are known to be high risk.

Clinical Trial Description

PRIMARY OBJECTIVE: I. Evaluate the effectiveness and sustainability of heritable cancer syndrome testing in two proposed screening populations compared to current guidelines. SECONDARY OBJECTIVES: I. Measure adherence to current guidelines for screening and prophylactic intervention of Cohorts B and C compared to Cohort A to show non-inferiority. II. Measure the efficiency of cascade testing (defined as the ratio of family members screened over total possible) for Cohorts B and C compared to Cohort A to show non-inferiority. III. Determine the costs and effectiveness, specifically quality adjusted life years (QALYs) associated with genetic screening models based on Cohorts B and C to estimate incremental cost-effectiveness ratio (ICER) and show that the costs per QALY are below the acceptable cost effectiveness threshold. OUTLINE: Patients undergo collection of saliva samples for genetic testing. If genetic test is positive, patients receive genetic counseling. Patients also complete a survey about cancer prevention, screening, and treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04494945
Study type Interventional
Source OHSU Knight Cancer Institute
Contact
Status Recruiting
Phase N/A
Start date March 9, 2020
Completion date June 10, 2030
View Details
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