Study of HF10 in Patients With Refractory Head and Neck Cancer or Solid Tumors With Cutaneous and/or Superficial Lesions

Malignant Melanoma Clinical Trial

Official title:

Phase I Trial of Intratumoral Administration of HF10, A Replication Competent Herpes Simplex Virus Type 1, in Patients With Refractory Head and Neck Cancer or Solid Tumors With Cutaneous and/or Superficial Lesions

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01017185
• Other study ID #: M06-10083
• Status: Completed
• Phase: Phase 1
• Start date: August 2009
• Est. completion date: March 2015

Study information

• Verified date: May 2015
• Source: Takara Bio Inc.
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine whether HF10 is safe and effective in the treatment of head and neck cancer or solid tumors with cutaneous and/or superficial lesions.

Description:

This is an open label, non-randomized, multicenter, two-stage, dose escalation Phase I study evaluating single and repeated intratumoral injections of the oncolytic virus, HF10, in patients with refractory head and neck cancer, or solid tumors with cutaneous and/or superficial lesions (e.g., squamous cell carcinoma of the skin, carcinoma of the breast, and malignant melanoma).

Stage 1: Stage 1 of the study will investigate dose escalation of a single intratumoral injection over the following dose levels: 1 x 10^5 TCID50, 3 x 10^5 TCID50, 1 x 10^6 TCID50, and 1 x 10^7 TCID50. In Stage 1, it is planned that 3 patients will be enrolled per single dose cohort. Within each single dose cohort, accrual will temporarily be suspended after the first patient is entered and the patient will be followed for safety and for viral distribution and elimination. The patients in Stage 1 must be seropositive for HSV-1.

Stage 2: Stage 2 will evaluate repeated intratumoral injections of HF10 at dose levels of 1 x 10^6 TCID50/dose and 1 x 10^7 TCID50/dose. Three patients will be enrolled in each of the repeated dose cohorts. In Stage 2, the first patient treated in each repeated dose cohort must be seropositive for HSV-1. Patients in the repeated dose cohort will receive a total of four intratumoral injections in the same lesion.

Following completion of dosing in the repeated dose cohorts, an expansion cohort of three additional patients will be treated at the highest tolerated dose level.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 28
• Est. completion date: March 2015
• Est. primary completion date: May 2014
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria

• Patients must have histologically confirmed solid tumors that have failed standard therapies (surgery, chemotherapy, radiotherapy, or endocrine therapy) and for which no curative options exist, including, but not limited to:

• Squamous cell carcinoma of the head and neck

• Squamous cell carcinoma of the skin

• Carcinoma of the breast

• Malignant melanoma

• Patients may have had any kind and number of prior cancer therapies.

• Patients must have measurable non-visceral lesions that are evaluable by the RECIST method

• The tumor mass to be treated must be non-visceral and adequate for injection (i.e., more than 2 cm away from major vascular structures) and measurement by RECIST.

• Patients in Stage 1 must be seropositive for HSV-1.

• The first patient enrolled into each cohort in Stage 2 must be seropositive for HSV-1.

• Patients must be = 18 years of age.

• Patients must have a life expectancy = 12 weeks

• Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2.

• Patients must have adequate hepatic function, as defined as

• Total bilirubin levels = 1.5 x upper limit of normal (ULN)

• AST/ALT levels = 2.5 x ULN, or = 5 x ULN if liver metastases are present

• Patients must have adequate renal function as defined as serum creatinine = 1.5 x ULN or creatinine clearance (calculated) = 60 mL/min/1.73 m2 for patients with creatinine > 1.5 x ULN

• Patients must have adequate bone marrow function, as defined as

• Absolute neutrophil count = 1,500/µL and

• Platelet count = 100,000/µL

• Patients must have no known bleeding diathesis or coagulopathy that would make intratumoral injection or biopsy unsafe.

• Men and women of childbearing potential must agree to use adequate contraception prior to study entry and for up to six months.

• Females of childbearing potential must have a negative urine or serum pregnancy test within one week prior to start of treatment.

• Patients must be able to understand and willing to sign a written informed consent document.

Exclusion Criteria

• Patients receiving chemotherapy or radiotherapy within 4 weeks of injection of HF10, or adverse events > Grade 1, except alopecia, resulting from agents administered more than 4 weeks prior to HF10 injection.

• Patients with a history of significant tumor bleeding, or coagulation or bleeding disorders.

• Patients with nasopharyngeal tumors.

• Patients with deep (below the platysma muscle layer) ulcerative tumors.

• Patients with target tumors that could potentially invade a major vascular structure(s) (e.g., innominate artery, carotid artery), based on unequivocal imaging findings, as determined by a radiologist.

• Patients with Grade = 1 pre-existing neurologic abnormalities (CTCAE version 3.0).

• Patients who have been hospitalized for emergent conditions requiring inpatient evaluation, treatment or procedure during the 30 days prior to entry on study. In addition, emergent conditions requiring inpatient evaluation, treatment or procedure must have resolved or be medically stable and not severe for 30 days prior to entry on study.

• Patients with clinically evident Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), Hepatitis C virus (HCV), or Epstein-Barr virus (EBV) infection. Patients will be tested for HIV during pre-treatment screening.

• Patients receiving steroids or immunosuppressive agents, e.g., for rheumatoid arthritis

• Concurrent use of any other investigational agents.

• Presence or history of central nervous system metastasis.

• Pregnant or breastfeeding women;women desiring to become pregnant within the timeframe of the study are also excluded.

• Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.

Related Conditions & MeSH terms

• Breast Neoplasms
• Carcinoma
• Carcinoma of the Breast
• Carcinoma, Squamous Cell
• Head and Neck Neoplasms
• Malignant Melanoma
• Melanoma
• Refractory Head and Neck Cancer
• Squamous Cell Carcinoma, Skin

Intervention

Drug:
• HF10

Locations

Country	Name	City	State
United States	Montefiore Medical Center	Bronx	New York
United States	Mary Crowley Cancer Research Center	Dallas	Texas
United States	University of Pittsburgh	Pittsburgh	Pennsylvania
United States	Oregon Health and Science University	Portland	Oregon
United States	Huntsman Cancer Institute	Salt Lake City	Utah

Sponsors (1)

Lead Sponsor	Collaborator
Takara Bio Inc.

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Assessment of the local tumor response of the HF10-injected tumor by a modified target Response Evaluation Criteria In Solid Tumors (RECIST) method		one year
Secondary	Adverse events, vital signs, electrocardiogram(ECG), clinical laboratory tests, and physical exercise		one year
Secondary	Histological tumor response by biopsy		one year
Secondary	Overall tumor response of the HF10-injected tumor plus additional non-injected target tumors.		one year