Effect of Two Doses of Coenzyme Q10 on Seminal Fluid and Semen Antioxidant Status

Male Infertility Clinical Trial

Official title:

The Effect of Two Doses of Coenzyme Q10 on Seminal Fluid Parameters and Antioxidant Status: A Randomised Controlled Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03850561
• Other study ID #: EC/2018/8878
• Status: Completed
• Phase: N/A
• Start date: June 1, 2018
• Est. completion date: January 25, 2019

Study information

• Verified date: February 2019
• Source: University of Sumer
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The study was conducted to assess the impact of two doses of coenzyme Q10 on seminal fluid parameters and antioxidant status in infertile men.

Description:

The aim of this study was to assess the impact of two doses of coenzyme Q10 on seminal fluid parameters and antioxidant status in infertile men with idiopathic oligoasthenoteratospermia.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 65
• Est. completion date: January 25, 2019
• Est. primary completion date: November 20, 2018
• Accepts healthy volunteers: No
• Gender: Male
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• History of infertility of at least 12 months despite regular unprotected intercourse.

Oligoasthenoteratospermia was diagnosed by semen analysis showing abnormal sperm concentration (<15 million/ml), progressive motility (<32%), total motility (<40%) and morphology (<30% WHO criteria) as defined by WHO manual for semen analysis 2010

Exclusion Criteria:

• Azoospermia,

• Varicocele,

• Genital tract infection,

• Cryptorchidism,

• Testicular trauma or scrotal surgery,

• Endocrine disorder,

• Systemic illness,

• Smoking

• The presence of female factor

Related Conditions & MeSH terms

• Infertility
• Infertility, Male
• Male Infertility

Intervention

Dietary Supplement:
• Coenzyme Q10 200
Coenzyme Q10 200 mg/day
• Coenzyme Q10 400
Coenzyme Q10 400 mg/day

Locations

Country	Name	City	State
Iraq	Fertility Unit, Babyl	Hilla

Sponsors (1)

Lead Sponsor	Collaborator
University of Sumer

Country where clinical trial is conducted

Iraq, 

References & Publications (3)

Alahmar AT. The effects of oral antioxidants on the semen of men with idiopathic oligoasthenoteratozoospermia. Clin Exp Reprod Med. 2018 Jun;45(2):57-66. doi: 10.5653/cerm.2018.45.2.57. Epub 2018 Jun 29. Review. — View Citation

Alshahrani S, Aldossari K, Al-Zahrani J, Gabr AH, Henkel R, Ahmad G. Interpretation of semen analysis using WHO 1999 and WHO 2010 reference values: Abnormal becoming normal. Andrologia. 2018 Mar;50(2). doi: 10.1111/and.12838. Epub 2017 Aug 3. — View Citation

Nadjarzadeh A, Shidfar F, Amirjannati N, Vafa MR, Motevalian SA, Gohari MR, Nazeri Kakhki SA, Akhondi MM, Sadeghi MR. Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial. Andrologia. 2014 Mar;46(2):177-83. doi: 10.1111/and.12062. Epub 2013 Jan 7. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Semen volume (WHO 2010 guidelines)	Semen volume in ml	3 months
Primary	Sperm concentration in semen (WHO 2010 guidelines)	Sperm concentration in million/ml	3 months
Primary	Sperm motility in semen (WHO 2010 guidelines)	Sperm motility (%)	3 months
Primary	Sperm morphology in semen (WHO 2010 guidelines)	Normal sperm morphology (%)	3 months
Primary	Seminal plasma TAC	Seminal plasma total antioxidant capacity in mmol/ml	3 months
Primary	Seminal plasma CAT	Seminal plasma catalase in U/ml	3 months
Primary	Seminal plasma SOD	Superoxide dismutase in U/ml	3 months