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FDG PET and DCE-MRI in Predicting Response to Treatment in Patients With Breast Cancer

Stage IIIA Breast Cancer Clinical Trial

Official title:
Quantitative Dynamic PET and MRI and Breast Cancer Therapy

Clinical Trial Summary

This clinical trial studies fludeoxyglucose F 18 (FDG) positron emission tomography (PET) and dynamic contrast-enhanced (DCE)-magnetic resonance imaging (MRI) in predicting response to treatment in patients with breast cancer. Comparing results of diagnostic procedures done before, during, and after chemotherapy may help doctors predict a patient's response to treatment and help plan the best treatment.

Clinical Trial Description

PRIMARY OBJECTIVES: I. To determine whether detailed kinetic analysis of FDG PET and magnetic resonance (MR) imaging studies for measures of tumor metabolism and blood perfusion can predict response and outcome for breast cancer patients undergoing neo-adjuvant therapy. II. To compare the in vivo tumor biology associated with responsive and resistant tumors as measured by kinetic changes in FDG PET and MR imaging parameters to tumor subtypes analyzed from assay of pre-therapy biopsy and post-therapy surgical tissue. OUTLINE: Patients undergo FDG PET and DCE-MRI 1-2 weeks before prior to chemotherapy initiation, between 1-12 weeks after initiation of the first course of chemotherapy, and after the completion of chemotherapy (within 4 weeks prior to surgery). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01931709
Study type Interventional
Source University of Washington
Contact
Status Terminated
Phase N/A
Start date November 2011
Completion date October 26, 2022
View Details
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