Malaria Clinical Trial
Official title:
Contrast-Enhanced US of Spleen, Liver and Kidney in Patients With Acute Infection (Malaria and Other Infectious Diseases: a Functional Study
To evaluate the changes in the microcirculation of the liver, kidney and spleen during acute
infection in patients with malaria (cohorts 1 and 3) and other infectious diseases such as
acute pyelonephritis at day 0 (within 8 hours of the treatment start), day 2 to 4 and day
28-32, using functional US with continuous infusion of a contrast agent (SonoVue, Bracco,
Italy).
Study hypothesis: malaria patients should exhibit a different pattern of enhancement,
particularly when quantitative measurements of the SU signals is performed with destruction
reperfusion kinetics.
To evaluate the changes in the microcirculation of the liver, kidney and spleen during acute
infection in patients with malaria (cohorts 1 and 3) and other infectious diseases such as
acute pyelonephritis at day 0 (within 8 hours of the treatment start), day 2 to 4 and day
28-32, using functional US with continuous infusion of a contrast agent (SonoVue, Bracco,
Italy).
Three cohortes will be studied: cohorte 1 infection at Plasmodium falciparum (24 patients),
cohorte 3 infection at Plasmodium vivax, ovale or malariae (5 patients) and cohorte 2 other
infectious diseases such as acute pyelonephritis (24 patients).
Study hypothesis: malaria patients should exhibit a different pattern of enhancement,
particularly when quantitative measurements of the SU signals is performed with destruction
reperfusion kinetics.
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Observational Model: Defined Population, Time Perspective: Longitudinal
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