Major Depression Clinical Trial
There is a general consensus of efficacy of TMS in treatment of major depression,yet results
are not satisfying.A new coil ("H"-coil, recently invented in Weizmann Institute of Science,
Neurobiology Department, Rehovot, Israel) is supposed to be capable of stimulating deeper
brain structures than conventional coils.TMS using this coil was named by its developers as
"deep TMS" and will hence be refered to by this name.
So far, deep TMS have studied in Israel with promising sucssess in patients with Major
depression (An on-going study).A safety study with good results have been recently
published.The aim of this study is to reinforce initial results in major depression using
deep TMS.
A group of 40 patients with major depression will be randomly assigned to deep TMS with H-1 coil in frequency of 20 HZ or H-2 coil in frequency of 0.1 HZ with 120% of motor threshold to the prefrontal cortex . No change in anti-depressant medication one month prior to study is a prerequisite.Deep TMS will be administered for 4 weeks.During TMS exposure subjects will be exposed to a conversation in which they talk about their depression and their ruminations.Patients will be evaluated using Hamilton Depression Rating Scale (HAM-D24),Hamilton Anxiety Rating Scale (HAM-A),Clinical Global Impression - Improvement(CGI-I) ,Beck Depression Inventory (BDI),Visual Analog Scale (VAS). ;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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