Treatment Choices for Improving Adherence and Outcome

Major Depression Clinical Trial

Official title:

Patient Preference in Primary Care Depression Treatment

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00194948
• Other study ID #: K23MH069784
• Secondary ID: K23MH069784DSIR
• Status: Completed
• Phase: N/A
• First received: September 12, 2005
• Last updated: November 1, 2013
• Start date: September 2003
• Est. completion date: May 2007

Study information

• Verified date: November 2013
• Source: Weill Medical College of Cornell University
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Interventional

Clinical Trial Summary

This study will determine the effectiveness of offering primary care patients their preferred treatment versus one that is less desirable in improving treatment adherence and outcome.

Description:

This study investigates whether offering primary care patients treatment that is congruent with their preferred first choice improves adherence and outcomes, in comparison to offering treatment that is not congruent with their preferred first choice. All subjects are offered a treatment with demonstrated efficacy, namely either the antidepressant medication escitalopram or Interpersonal Psychotherapy for 5 months. We hypothesize that patients who receive congruent treatment will be more likely to initiate treatment, adhere to treatment, and achieve depression remission.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: May 2007
• Est. primary completion date: April 2007
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 21 Years and older

Eligibility

Inclusion Criteria:

• age 21-99

• English-speaking

• DSM-IV criteria for major depression

Exclusion Criteria:

• unable to give informed consent

• MMSE<24

• DSM-IV diagnosis of bipolar disorder, psychotic disorder, current alcohol or substance abuse

• active suicide ideation

• aphasia

• acute or severe medical illness

• currently receiving either antidepressant medication or psychotherapy

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Depression
• Depressive Disorder, Major
• Major Depression

Intervention

Drug:
• escitalopram

Behavioral:
• interpersonal psychotherapy

Locations

Country	Name	City	State
United States	Cornell Internal Medicine Associates	New York	New York
United States	Weill Medical College of Cornell University	White Plains	New York

Sponsors (2)

Lead Sponsor	Collaborator
Weill Medical College of Cornell University	National Institute of Mental Health (NIMH)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	treatment initiation
Primary	treatment adherence
Secondary	depressive symptomatology