Major Depression (in Remission) Clinical Trial
Official title:
Investigating the Neuropsychological Mechanisms Underlying Mindfulness-based Cognitive Therapy
This research will investigate the neuropsychological mechanisms underlying the eight-week
Mindfulness-based Cognitive Therapy (MBCT) programme.
Participants in remission from depression will be seen pre- and post-MBCT to assess the
underlying neuropsychological mechanisms. All will be followed-up over 12 months to assess
the relationship of these neuropsychological changes with relapse risk.
The research will focus primarily on changes in self-compassion, rumination, attention and
structural brain changes, with secondary focus on other mechanisms of emotional processing
and memory.
There will be three groups in total.
- The first group will take 36 participants in remission from major depression (rMDD)
through the 8 week MBCT program.
- A control group of 36 rMDD participants will not receive the intervention.
- A group of never depressed healthy control participants will also be recruited.
Research visits for participants not undergoing MBCT will be separated by an 8 week gap.
All participants will be seen before and after the 8 weeks for completion of
neuropsychological assessments and questionnaires.
rMDD participants will be followed up over the following 12 months to identify any predictors
of relapse.
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