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Clinical Trial Summary

This research will investigate the neuropsychological mechanisms underlying the eight-week Mindfulness-based Cognitive Therapy (MBCT) programme.

Participants in remission from depression will be seen pre- and post-MBCT to assess the underlying neuropsychological mechanisms. All will be followed-up over 12 months to assess the relationship of these neuropsychological changes with relapse risk.

The research will focus primarily on changes in self-compassion, rumination, attention and structural brain changes, with secondary focus on other mechanisms of emotional processing and memory.


Clinical Trial Description

There will be three groups in total.

- The first group will take 36 participants in remission from major depression (rMDD) through the 8 week MBCT program.

- A control group of 36 rMDD participants will not receive the intervention.

- A group of never depressed healthy control participants will also be recruited.

Research visits for participants not undergoing MBCT will be separated by an 8 week gap.

All participants will be seen before and after the 8 weeks for completion of neuropsychological assessments and questionnaires.

rMDD participants will be followed up over the following 12 months to identify any predictors of relapse. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02226042
Study type Interventional
Source University of Manchester
Contact
Status Completed
Phase N/A
Start date October 2014
Completion date October 2017