Atorvastatin ± Aspirin in Lynch Syndrome Syndrome

Status Recruiting

Clinical Trial Summary

The goal of this study is to investigate that a common cholesterol lowering agent (atorvastatin) alone or combining with a nonsteroidal anti-inflammatory drug (aspirin) would reduce the risk of colorectal cancer (CRC) in high-risk individuals with Lynch syndrome.

Clinical Trial Description

This is an exploratory biomarker trial to assess the ability of atorvastatin (common cholesterol lowering agent) alone or combining with aspirin (a nonsteroidal anti-inflammatory drug) to reduce the risk of colorectal cancer in high-risk individuals with Lynch Syndrome. Subjects will be stratified based on their prior history of polyps/cancer to receive atorvastatin without or with aspirin for 6 weeks. Blood and normal colon biopsies will be obtained at Day 0 and at 6 weeks on study. Tissue endpoints for analysis include cell proliferation, apoptosis and changes in gene expression. Circulating lipid profiles and metabolic function, and post-treatment questionnaires will be used to assess the acceptability of the study. ;

Study Design

Related Conditions & MeSH terms

Colorectal Neoplasms, Hereditary Nonpolyposis
Lynch Syndrome
Syndrome

Clinical Trial Details

NCT number	NCT04379999
Study type	Interventional
Source	Fox Chase Cancer Center
Contact	Yana Chertock, MA
Phone	215-214-3216
Email	yana.chertock@fccc.edu
Status	Recruiting
Phase	Early Phase 1
Start date	September 10, 2018
Completion date	September 10, 2023

View Details

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