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Lymphoma clinical trials

View clinical trials related to Lymphoma.

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NCT ID: NCT05931328 Recruiting - Clinical trials for Relapsed or Refractory (R/R) Primary Central Nervous System Lymphoma

The Study of the Combination of Thiotepa and Pomalidomide for the Treatment of Relapsed/Refractory Primary Central Nervous System Lymphoma Patients.

Start date: October 15, 2022
Phase: Phase 2
Study type: Interventional

The aim of this study is to evaluate the efficacy and safety of the combination of thiotepa and pomalidomide in the treatment of relapsed/refractory (R/R) primary central nervous system lymphoma (PCNSL).

NCT ID: NCT05929716 Withdrawn - B-cell Lymphoma Clinical Trials

An Open-Label, Single Center Phase 2 Study of Magrolimab, Rituximab and Radiation as Bridging Strategy Before CAR T-Cell Therapy in Patients With Relapsed or Refractory Large B-cell Lymphoma

Start date: September 30, 2023
Phase: Phase 2
Study type: Interventional

To evaluate the efficacy of the combination of magrolimab, rituximab, and radiation as bridging therapy in patients with relapsed or refractory LBCL who receive CAR T-Cell Therapy (CART).

NCT ID: NCT05929612 Recruiting - Lymphoma Clinical Trials

A Study of Response Adapted Ultra Low Dose 4 Gy Radiation for Definitive Therapy of Marginal Zone Lymphoma

Start date: July 28, 2023
Phase: Phase 2
Study type: Interventional

To learn if response-adapted, ultra-low dose radiation therapy can help to control MZL. This means participates first receive lower does of radiation therapy and then, based on how the disease responds, may receive higher doses after that.

NCT ID: NCT05929222 Recruiting - Follicular Lymphoma Clinical Trials

Comparison Between Local Radiotherapy Alone or Combined With Obinutuzumab in Early Stage Follicular Lymphoma: the GAZEBO Trial From the Fondazione Italiana Linfomi

FIL_GAZEBO
Start date: December 14, 2023
Phase: Phase 3
Study type: Interventional

Prospective, multicenter, open label, phase III randomized clinical trial in previously untreated Follicular Lymphoma in early stage. Patients will be randomized to receive Radiotherapy or Radiotherapy plus Obinutuzumab.

NCT ID: NCT05927558 Recruiting - Relapse Clinical Trials

Salvage Treatment With Glofitamab in R/R B-NHL: a GIMEMA-FIL Study

Start date: December 22, 2023
Phase:
Study type: Observational

The goal of this observational study is to evaluate the anti-lymphoma activity of glofitamab, administered according to the Compassionate Use Program, in relapsed/refractory B-NHL patients. The main question it aims to answer is the rate of patients in complete response.

NCT ID: NCT05926427 Recruiting - CNS Lymphoma Clinical Trials

Orelabrutinib Combined With Rituximab and Chemotherapy for Relapsed/Refractory B-Cell Lymphoma Patients With Central Nervous System Involvement

Start date: August 10, 2023
Phase: Phase 2
Study type: Interventional

This single-center, open, single-arm study aim to evaluate the efficacy and tolerability of a therapy introducing orelabrutinib on the basis of rituximab and chemotherapy in treating patients with relapsed or refractory B-cell lymphoma invloving central nervous system.

NCT ID: NCT05923879 Not yet recruiting - Clinical trials for Lymphoma, Large B-Cell, Diffuse

Mechanism Investigation of Selinexor Combined With Lenalidomide and Rituximab in the Treatment of Diffuse Large B-cell Lymphoma

Start date: June 30, 2023
Phase:
Study type: Observational

This is a retrospective observational study of the therapeutic mechanism and resistance mechanism of the treatment of Selinexor combined with lenalidomide and rituximab in diffuse large B-cell lymphoma patients. By detecting the immune cells in peripheral blood and tumor tissues of patients before and after treatment, the key immune cell subsets and immune molecules linked to the action and resistance of the treatment of Selinexor combined with lenalidomide and rituximab, so as to provide the basis for the optimization of the treatment or the combination of other immunotherapies.

NCT ID: NCT05923502 Not yet recruiting - Follicular Lymphoma Clinical Trials

(CHANT)Real World Study of Duvelisib in the Treatment of Non-Hodgkin's Lymphoma (NHL)

Start date: October 20, 2023
Phase:
Study type: Observational

This is a multicenter, non-interventional and prospective real-world study to evaluate the efficacy and safety of Duvelisib capsules in patients with non-Hodgkin's lymphoma.

NCT ID: NCT05922904 Recruiting - Hodgkin Lymphoma Clinical Trials

PET Adapted Brentuximab Vedotin and Pembrolizumab in Combination With Doxorubicin and Dacarbazine in Classic Hodgkin Lymphoma

Start date: December 14, 2023
Phase: Phase 2
Study type: Interventional

To learn about the effects of brentuximab vedotin and pembrolizumab in combination with doxorubicin and dacarbazine when given to patients who have Stage II cHL with bulky mediastinal disease or advanced cHL (Stage III or IV) and who have not received treatment for the disease.

NCT ID: NCT05922384 Recruiting - HIV Infections Clinical Trials

Safety and Efficacy Study of KL-7SHRNA Injection Solution in the Treatment of AIDS Patients With Lymphoma

Start date: July 5, 2023
Phase: N/A
Study type: Interventional

This pilot clinical trial studies gene therapy in treating patients with HIV-1 infecetion combined with lymphoma undergoing 7shRNA lentiviral vector transduced CD34+ hematopoietic stem cell transplant. Giving chemotherapy before a stem cell transplant stops the growth of cancer cells by stopping them from dividing or killing them. After treatment, CD34+hematopoietic stem cells are mobilized and collected from the patient's peripheral blood. The CD34+stem cells are then isolated and transduced with lenti-7shRNA vector and reinfused to the patient to replace the blood-forming cells that were destroyed by the chemotherapy.