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Clinical Trial Summary

To evaluate the efficacy of the combination of magrolimab, rituximab, and radiation as bridging therapy in patients with relapsed or refractory LBCL who receive CAR T-Cell Therapy (CART).


Clinical Trial Description

Primary Objectives: To evaluate the efficacy of the combination of magrolimab, rituximab and radiation as bridging therapy in patients with relapsed or refractory LBCL who receive CART. Secondary Objectives: To evaluate safety and tolerability of magrolimab, rituximab and radiation as bridging therapy in patients with relapsed or refractory LBCL who receive CART. Exploratory Objective: To determine the pharmacodynamic effects and investigate biomarkers of response and resistance to this bridging therapy. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05929716
Study type Interventional
Source M.D. Anderson Cancer Center
Contact
Status Withdrawn
Phase Phase 2
Start date September 30, 2023
Completion date March 1, 2028

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