T-Cell Lymphoma Clinical Trial
Official title:
Phase I Study of CHOP Plus Campath (C-CHOP) for the Treatment of T-Cell, Null-Cell, and NK-Cell Lymphomas
Primary Objective:
- To determine the toxicity profile and tolerability of alemtuzumab (Campath) when
administered in combination with cyclophosphamide, doxorubicin, vincristine, and
prednisone (CHOP) chemotherapy (C-CHOP) in patients with T-cell, null-cell and NK-cell
lymphomas.
Secondary Objectives:
- To evaluate response rate, overall survival, and disease-free survival in patients with
T-cell, null-cell, and NK-cell lymphomas treated with Campath + CHOP chemotherapy.
- To assess the incidence of cytomegalovirus (CMV) reactivation in patients with these
lymphomas treated with the Campath + CHOP combination.
- To determine features which might be predictive of resistance to treatment or
predictive of relapse, including the absence of glycosylphosphatidylinositol
(GPI)-linked proteins.
n/a
Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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