Lung Transplant Clinical Trial
Official title:
Impact of Cold Ischemia on Pulmonary Endothelial Dysfunction in Ex-vivo Pulmonary Reconditioning
The study population will be patients with planned double-lung transplant, with preoperative
ex-vivo reconditioning procedure.
The ex-vivo procedure will be performed for lungs considered as limit to be directly
implanted according to the national classification or in case of Maastrich 3 decision. They
required a rehabilitation procedure like ex-vivo to determine their quality. Once the
procedure initiated, the unused remaining liquid will be retrieved for the first gasometry
usually performed. This will be the time T1 of sampling.
The unused remaining liquid will be retrieved for the gasometry of end of procedure usually
performed, before the graft cooling. This will be the time T2.
The purge liquid of first lung at the declamping of the pulmonary artery will be retrieved at
the time of unclamping (time T3 of sampling).
The purge liquid of the second lung at the declamping of the pulmonary artery will be
retrieved with the same procedure (time T4 of sampling).
The samples will be analysed with ELISA technique. The endothelial dysfunction will be
evaluated with plasma concentration of heparan sulphate, syndecan-1, endothelin-1 and i-NOS.
n/a
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