Lung Diseases Clinical Trial
To examine the relationship between obstructive sleep apnea and lipid metabolism.
BACKGROUND:
Recent findings suggest interrelationships between obstructive sleep apnea, lipid
metabolism, and neurodegeneration. Apolipoprotein E epsilon4 (APOE e4), a genetic marker
linked to increased cardiovascular disease (CVD) risk and Alzheimer's disease (AD), is
associated with a two fold increased risk of sleep disordered breathing (SDB), and an
increase in severity of apnea symptoms. Preliminary data suggest that this association is
stronger between the ages of 50 and 65. Other experiments suggest dysregulated leptin levels
in obstructive sleep apnea (OSA). Taken together, these findings suggest common
pathophysiological mechanisms involving dysregulated lipid metabolism in OSA. An
understanding of these mechanisms is essential for the prevention and treatment of SDB.
DESIGN NARRATIVE:
Using case/control and family designs, the study: 1) extends the finding that apolipoprotein
E epsilon4 (APOE e4) increases the risk of sleep apnea in the general population; 2)
examines if polymorphisms in other genes regulating lipid levels are associated with sleep
apnea; 3) studies the relationship between lipid regulatory gene polymorphisms, lipid
profile (LDL- cholesterol, HDL-cholesterol, triglycerides), plasma leptin (and other lipid
regulatory hormones), and sleep apnea levels.
T
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