Clinical Trials Logo
  1. Home
  2. Lung Diseases, Obstructive
  3. NCT04842344

ECCO2R in the Treatment of Acute Exacerbation of COPD With Severe Hypercapnia

Lung Diseases, Obstructive Clinical Trial

Official title:
A Prospective Randomized Controlled Trial of Extracorporeal Carbon Dioxide Removal (ECCO2R) in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Severe Hypercapnia

Clinical Trial Summary

Patients with moderate to severe acute exacerbation of chronic obstructive pulmonary disease are often complicated with hypercapnia and respiratory failure, so they need to be admitted to ICU for monitoring and respiratory support treatment. Noninvasive ventilation has become the first-line respiratory support for the treatment of AECOPD with hypercapnia and respiratory failure. However, 26-54% of AECOPD patients with hypercapnia and respiratory failure eventually fail to receive noninvasive ventilation and need endotracheal intubation and invasive ventilation to maintain effective gas exchange. For these patients, the in-hospital survival rate is only 31-76%, and the prognosis is poor. In AECOPD patients with high risk of noninvasive ventilation failure and expected need of intubation, timely giving other ways of respiratory support to reduce blood CO2 may avoid patients receiving tracheal intubation and invasive ventilation, thus avoiding related complications and adverse prognosis. As a new type of respiratory support technology, ECCO2R is worthy of attention in monitoring and evaluation of support effect in AECOPD patients with respiratory failure. It is urgent that ECCO2R can effectively alleviate respiratory failure, avoid complications related to tracheal intubation, improve quality of life and reduce mortality.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04842344
Study type Interventional
Source Beijing Chao Yang Hospital
Contact Xuyan Li, MD
Phone 86013581851048
Email araklee@163.com
Status Recruiting
Phase N/A
Start date May 1, 2021
Completion date March 31, 2024
View Details
See also
  Status Clinical Trial Phase
Completed NCT01860898 - A Phase I Study of iPS Cell Generation From Patients With COPD N/A
Completed NCT00281229 - T Lymphocyte Cells in Individuals Experiencing an Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Completed NCT00281242 - Changes in Cytokine Levels During an Acute Exacerbation of Chronic Obstructive Pulmonary Disease N/A
Completed NCT00281203 - Comparison of Alveolar Macrophages in Healthy Individuals Versus Individuals With COPD N/A
Completed NCT00281190 - Comparison of Alveolar Macrophages in Individuals With COPD Versus Smokers With Normal Pulmonary Function N/A
Completed NCT00281216 - Innate and Adaptive Immunity in Individuals Experiencing Chronic Obstructive Pulmonary Disease Exacerbations N/A
Completed NCT00159341 - Cigarette Smoke Nasal and Whole Blood Challenge in Patients With Chronic Obstructive Pulmonary Disease (COPD) Phase 1
Completed NCT00069823 - Study of Acid Reflux in Asthma Phase 3
Completed NCT00006513 - Assessing the Occupation Burden in COPD N/A
Completed NCT00000621 - Feasibility of Retinoic Acid Treatment in Emphysema (FORTE) Phase 2
Completed NCT00006306 - Effects of Chronic Ozone Exposure on Lung Function N/A
Completed NCT00000569 - Lung Health Study II Phase 3
Completed NCT00005425 - Statistical Analysis of Vlagtwedde-Vlaardingen Data Set N/A
Completed NCT00005720 - Lay-Led Smoking Cessation Approach for Southeast Asian Men N/A
Completed NCT00000568 - Lung Health Study (LHS) I and III Phase 3
Completed NCT00005281 - Early Risk Predictors For Chronic Pulmonary Disease N/A
Not yet recruiting NCT05286918 - Antibiotic Stewardship in AECOPD Through CRP-Guided Management N/A
Recruiting NCT05565872 - Effects of Supervision During a Community-based Exercise Intervention (Urban Training) in Patients With COPD N/A
Not yet recruiting NCT02928666 - Integration of Guidelines for Comorbidities N/A
Completed NCT02306473 - The Leaky Lung Test Early Phase 1